gene

DNAJC13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

50Outgoing

14Incoming

0Experiments

0Debates

Summary

Gene: DNAJC13 — DnaJ Heat Shock Protein Family Member C13 (RME-8)

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🧬 Gene Info

Gene Symbol	DNAJC13
Full Name	DnaJ Heat Shock Protein Family Member C13
Aliases	RME-8
Chromosome	3q22.1
Protein Type	Chaperone
Function	is a co-chaperone protein primarily localized to endosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control.
Primary Expression	neurons throughout the brain, particularly in dopaminergic neurons of the substantia nigra pars compacta
Subcellular Localization	endosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control. Ori
Molecular Weight	280 kDa
Amino Acids	558 aa
Exons	33
Pathways	mTOR, mtor
GeneCards	DNAJC13
Human Protein Atlas	DNAJC13
Early endosomes	Colocalizes with EEA1 and Rab5
Associated Diseases	Als, Alzheimer, Parkinson, PARKINSON DISEASE, Parkinson's disease
KG Connections	64 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC13["DNAJC13"]
    DNA["DNA"]
    DNAJC13 -->|"regulates"| DNA
    neurodegeneration["neurodegeneration"]
    DNAJC13 -->|"implicated in"| neurodegeneration
    DNA -->|"regulates"| DNAJC13
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"associated with"| DNAJC13
    AND["AND"]
    AND -->|"regulates"| DNAJC13
    style DNAJC13 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
GABARAP	regulates	gene	0.60
LC3	regulates	gene	0.60
neurodegeneration	regulates	disease	0.60
GBA1	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
DNA	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Parkinson's disease	associated_with	disease	0.60
HSC70	regulates	gene	0.60
neurons	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
MAP1LC3	regulates	gene	0.60
Parkinson's disease	regulates	disease	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
RAB39B	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
GBA	associated_with	gene	0.60
STING	regulates	gene	0.60
NEURON	co_discussed	cell_type	0.60
NEURON	causes	cell_type	0.60
PARKINSON DISEASE	causes	disease	0.60
PD	causes	gene	0.60
PD	co_discussed	gene	0.60
SNCA	co_discussed	gene	0.45
GBA	co_discussed	gene	0.45
FBXO7	co_discussed	gene	0.45
LRRK2	co_discussed	gene	0.45
PINK1	co_discussed	gene	0.45
PLA2G6	co_discussed	gene	0.45
PARK7	co_discussed	gene	0.40
TARDBP	co_discussed	gene	0.40
VPS35	co_discussed	gene	0.40
NEURONS	co_discussed	cell_type	0.40

Incoming (14)

Source	Relation	Type	Str
ATP13A2	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
DNA	regulates	gene	0.60
LYSOSOME	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
ATG	regulates	gene	0.60
AUTOPHAGY	regulates	pathway	0.60
AUTOPHAGY	causes	pathway	0.60
ATP13A2	co_discussed	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJC13 in their description or question text

No additional research found