Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FNIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | FNIP1 |
| Full Name | Folliculin Interacting Protein 1 |
| Chromosome | 5q31.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons across multiple brain regions including the cerebral cortex and hippocampus, as well as in glial cells such as astrocytes |
| Subcellular Localization | Primarily cytoplasmic, with some nuclear localization |
| Molecular Weight | 220 kDa |
| Amino Acids | 950 aa |
| Exons | 24 |
| Pathways | AMPK, mTOR, mtor, ampk, AMPK signaling |
| UniProt ID | Q8TF40 |
| NCBI Gene ID | 96459 |
| Ensembl ID | ENSG00000146232 |
| GeneCards | FNIP1 |
| Human Protein Atlas | FNIP1 |
| Associated Diseases | neurodegeneration |
| Interactions | AMPK, FLCN, TFEB |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
FNIP1(["FNIP1"])
GABARAP(["GABARAP"])
FLCN(["FLCN"])
AMPK(["AMPK"])
TFEB(["TFEB"])
neurodegeneration["neurodegeneration"]
GABARAP -->|"binds"| FNIP1
FNIP1 -->|"interacts with"| FLCN
FNIP1 -->|"activates"| AMPK
FNIP1 -->|"activates"| TFEB
FNIP1 -->|"implicated in"| neurodegeneration
style FNIP1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fffHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FNIP1 in their description or question text
No additional research found