gene 1,372 words KG: MAPK3
Contents

MAPK3 Gene - ERK1

🧬 Gene Info
Gene SymbolMAPK3
Full NameMitogen-Activated Protein Kinase 3
AliasesPage for MAPK3 Gene
Chromosome16p11.2
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a serine/threonine protein kinase encoded by the MAPK3 gene.
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight43 kDa
Amino Acids379 aa
PathwaysMAPK, mapk
UniProt IDP27361
GeneCardsMAPK3
Human Protein AtlasMAPK3
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsACTB, Akt, AKT, AKT1, APOPTOSIS, ATG5
KG Connections418 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: activates
ACTB Gene
gene · KG edge: interacts_with
ADRB2 Gene
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: activates

Knowledge Graph (12 edges)

AKT therapeutic_target MAPK3
PI3K therapeutic_target MAPK3
MAPK3 therapeutic_target JUN
MAPK3 therapeutic_target PTGS2
MAPK3 therapeutic_target HIF1A
MAPK3 therapeutic_target HSP90AA1
MAPK3 therapeutic_target VEGFA
MAPK3 therapeutic_target MDM2
MAPK3 therapeutic_target AKT1
MAPK3 associated_with MMP9

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