gene

SOD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

33Outgoing

11Incoming

0Experiments

0Debates

Summary

SOD3 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, protects against. Associated with Als, Amyotrophic Lateral Sclerosis, Atherosclerosis. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SOD3
Aliases	EC-SOD
Chromosome	4p15.2
Protein Type	Gene
Function	is a copper- and zinc-containing enzyme (Cu/ZnSOD) that is secreted into the extracellular space and the extracellular matrix [1].
Primary Expression	neurons, astrocytes, and particularly in vascular endothelial cells - Lungs: Highest expression in lung tissue - Heart
Molecular Weight	135 kDa
Amino Acids	366 aa
Exons	5
GeneCards	SOD3
Human Protein Atlas	SOD3
Heparin-binding domain	The C-terminal region contains a heparin-binding motif that localizes the enzyme to cell surfaces and the extracellular matrix [5]
Glycosylation	The protein is N-glycosylated, which affects its stability and tissue distribution [6]
Extracellular localization	Unlike SOD1 and SOD2, SOD3 functions primarily in the extracellular space [7]
Oxidative stress reduction	SOD3 neutralizes extracellular superoxide radicals that contribute to amyloid-beta (Aβ) toxicity and neuronal death [8]
Associated Diseases	Amyotrophic Lateral Sclerosis
Interactions	APOE, C/EBPβ, ERK1, GSH, HO1, NRF2
KG Connections	44 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SOD3 Gene

gene · 1148 words

→

SOD3 Protein (Extracellular Superoxide Dismutase)

protein · 1819 words

→

Pathway Diagram

graph TD
    SOD3["SOD3"]
    superoxide_anion["superoxide anion"]
    SOD3 -->|"inhibits"| superoxide_anion
    Diabetes{"Diabetes"}
    SOD3 -->|"inhibits"| Diabetes
    Fibrosis{"Fibrosis"}
    SOD3 -->|"inhibits"| Fibrosis
    Als{"Als"}
    SOD3 -->|"inhibits"| Als
    Cardiovascular{"Cardiovascular"}
    SOD3 -->|"inhibits"| Cardiovascular
    Inflammation{"Inflammation"}
    SOD3 -->|"inhibits"| Inflammation
    SOD3 -->|"activates"| Als
    Hypertension{"Hypertension"}
    SOD3 -->|"protects against"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    SOD3 -->|"protects against"| Atherosclerosis
    SOD3 -->|"protects against"| Cardiovascular
    Ms{"Ms"}
    SOD3 -->|"activates"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    SOD3 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    ERK["ERK"]
    ERK -->|"expressed in"| SOD3
    SOD2["SOD2"]
    SOD2 -->|"expressed in"| SOD3
    EGFR["EGFR"]
    EGFR -->|"expressed in"| SOD3
    SOD1["SOD1"]
    SOD1 -->|"activates"| SOD3
    SOD2 -->|"activates"| SOD3
    SOD1 -->|"expressed in"| SOD3
    style SOD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
superoxide anion	inhibits	phenotype	0.95
extracellular ROS	inhibits	process	0.95
cartilage extracellular matrix	preserves	phenotype	0.90
osteoarthritis	protects_against	disease	0.90
APOE	inhibits	gene	0.85
C/EBPβ	interacts_with	protein	0.80
Diabetes	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Hypertension	protects_against	disease	0.65
Atherosclerosis	protects_against	disease	0.65
Cardiovascular	protects_against	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
ALS	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60
SOD2	expressed_in	gene	0.60
EGFR	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
ERK1	inhibits	gene	0.60
NRF2	expressed_in	gene	0.60
TGF	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Tgf-Β	expressed_in	pathway	0.60
Angiogenesis	protects_against	pathway	0.60
Oxidative Stress	protects_against	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
ATOX1	upregulates	gene	0.80
SOD2	expressed_in	gene	0.60
EGFR	expressed_in	gene	0.60
SOD1	activates	gene	0.60
SOD2	activates	gene	0.60
HO1	activates	gene	0.60
NRF2	activates	gene	0.60
ERK	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
GSH	activates	gene	0.60
ROS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SOD3 in their description or question text

No additional research found