gene 608 words KG: EP300
Contents

EP300 Gene

🧬 Gene Info
Gene SymbolEP300
Chromosome22q13.2
Protein TypeTransferase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionUbiquitous, highest in brain
Molecular Weight300 kDa
Amino Acids414 aa
PathwaysNF-κB
GeneCardsEP300
Human Protein AtlasEP300
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma
Known Drugs/CompoundsAcetyl-CoA, rapamycin
InteractionsACAT1, AMPK, AND, ATG, AUTOPHAGY, BRD4
SciDEX Hypothesesp300/CBP-dependent K280 acetylation nucleates path
KG Connections572 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: expressed_in
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

OPTN associated_with EP300
ULK1 associated_with EP300
CALCOCO2 associated_with EP300
HSPA8 associated_with EP300
STX17 associated_with EP300
SQSTM1 associated_with EP300
KAT8 associated_with EP300
RB1CC1 associated_with EP300
SIRT1 associated_with EP300
LC3 associated_with EP300

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