concept

MICROTUBULES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROTUBULES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

435Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MICROTUBULES is a concept in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with ALS, Aging, Als. Connected to 162 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MICROTUBULES
Key Genes/Proteins	ABCB1, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMBRA1
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Expand Microtubules content

entity · 1565 words

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Pathway Diagram

graph TD
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"inhibits"| Ischemia["Ischemia"]
    MICROTUBULES -->|"inhibits"| Ms["Ms"]
    MICROTUBULES -->|"inhibits"| Tumor["Tumor"]
    MICROTUBULES -->|"activates"| Cancer["Cancer"]
    MICROTUBULES -->|"expressed in"| Aging["Aging"]
    MICROTUBULES -->|"expressed in"| Cardiac["Cardiac"]
    MICROTUBULES -->|"interacts"| Neurodegeneration["Neurodegeneration"]
    OPTN["OPTN"] -->|"binds"| MICROTUBULES
    KINESIN_1["KINESIN-1"] -->|"transports"| MICROTUBULES
    REEP1["REEP1"] -->|"stabilizes"| MICROTUBULES
    RAB7["RAB7"] -->|"activates"| MICROTUBULES
    MTOR["MTOR"] -->|"interacts"| MICROTUBULES
    ENDOSOMES["ENDOSOMES"] -->|"interacts"| MICROTUBULES
    BCL2["BCL2"] -->|"inhibits"| MICROTUBULES
    TLR4["TLR4"] -->|"inhibits"| MICROTUBULES
    MYD88["MYD88"] -->|"inhibits"| MICROTUBULES
    TNF["TNF"] -->|"inhibits"| MICROTUBULES

Outgoing (266)

Target	Relation	Type	Str
Organelle Transport	involved_in	process	0.95
Axon Development	involved_in	process	0.95
Dendrite Development	involved_in	process	0.95
Organelle Transport	mediates	process	0.90
Neurite Extension	involved_in	process	0.85
Golgi Complex	associated_with	cell_type	0.85
Cytoskeleton	associated_with	pathway	0.85
ALS	activates	disease	0.75
Als	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Hypertension	activates	disease	0.65
ALS	causes	disease	0.65
Aging	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Glaucoma	activates	disease	0.65
ALS	interacts_with	disease	0.65
Parkinson	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	causes	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Als	transports	disease	0.65
Tumor	regulates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cardiac	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Heart Failure	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Als	inhibits	disease	0.65
Huntington	causes	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65

Incoming (169)

Source	Relation	Type	Str
MAPT	interacts_with	protein	0.95
TAU	associated_with	protein	0.95
MAPT	component_of	protein	0.90
OPTN	binds	gene	0.90
MAP6	associated_with	protein	0.90
TAU	binds	gene	0.90
OPTN	interacts_with	protein	0.90
MAPT	regulates	protein	0.90
Tau	binds	protein	0.90
MAP6	interacts_with	protein	0.90
Tau	interacts_with	protein	0.90
DCX	interacts_with	protein	0.85
PAFAH1B1	interacts_with	protein	0.85
TAU	interacts_with	protein	0.85
MAPT	associated_with	gene	0.80
REEP1	stabilizes	gene	0.80
Actin Filaments	interacts_with	protein	0.75
TAU	stabilizes	gene	0.60
REELIN	causes	gene	0.60
DAB1	causes	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
STATHMIN	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
LYSOSOME	contributes_to	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
BCL-2	regulates	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
AMYLOID	causes	gene	0.60
SELECTIVE NEURODEGENERATION	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
HUNTINGTON'S DISEASE	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
LYST	regulates	gene	0.60
ATG1	regulates	gene	0.60
ATG5	regulates	gene	0.60
CLN5	regulates	gene	0.60
CTSD	regulates	gene	0.60
AND	causes	gene	0.60
AMPK	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
APAF1	associated_with	gene	0.60
GFP	activates	gene	0.60
HIPPO	expressed_in	gene	0.60
CDK5	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MICROTUBULES in their description or question text

No additional research found