| Gene Symbol | EIF4EBP1 |
| Full Name | Eukaryotic Translation Initiation Factor 4E Binding Protein 1 |
| Aliases | 4E-BP1 |
| Function | is a small (~117 amino acid) translational repressor protein that plays a critical role in regulating cap-dependent mRNA translation. |
| Molecular Weight | 12 kDa |
| Amino Acids | 117 aa |
| Pathways | mTOR, mtor, mTOR signaling |
| Ensembl ID | ENSG00000187840 |
| GeneCards | EIF4EBP1 |
| Human Protein Atlas | EIF4EBP1 |
| Unphosphorylated 4E-BP1 | High affinity for eIF4E, strong translation repression |
| Phosphorylated 4E-BP1 | Reduced eIF4E binding, releases the translational brake |
| Synaptic proteins | NMDA receptor subunits, AMPA receptor components |
| Transcription factors | c-Fos, Arc, CREB |
| Trophic factors | BDNF, NGF |
| Associated Diseases | Als, Ataxia, Cancer, Infection, Metabolic Syndrome |
| Known Drugs/Compounds | rapamycin |
| Interactions | 4E-BP1, ABCA1, ABCG1, ACTB, AKT, AKT1 |
| KG Connections | 330 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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