gene

PDPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

47Outgoing

21Incoming

0Experiments

0Debates

Summary

3-Phosphoinositide Dependent Protein Kinase 1 - master activator of AKT signaling in neuronal survival and neurodegeneration

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🧬 Gene Info

Gene Symbol	PDPK1
Full Name	3-Phosphoinositide Dependent Protein Kinase 1
Chromosome	16p13.3
Protein Type	Serine/Threonine Kinase
Function	encodes a serine/threonine kinase that serves as the master activator of the AKT signaling pathway and other AGC family kinases.
Pathways	PI3K, pi3k
UniProt ID	O15530
NCBI Gene ID	5170
Ensembl ID	ENSG00000124151
OMIM	605363
Associated Diseases	Infection
Interactions	AKT, AKT1, CANCER, DNA, EGFR, EIF4EBP1
KG Connections	68 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PDPK1 — AlphaFold O15530 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDPK1 Gene

gene · 2764 words

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Pathway Diagram

graph TD
    PDPK1["PDPK1"]
    AKT["AKT"]
    PDPK1 -->|"activates"| AKT
    RSK2["RSK2"]
    PDPK1 -->|"activates"| RSK2
    FasL["FasL"]
    PDPK1 -->|"activates"| FasL
    SDC2["SDC2"]
    PDPK1 -->|"binds"| SDC2
    miR_1183["miR-1183"]
    PDPK1 -->|"regulates"| miR_1183
    HOTAIR["HOTAIR"]
    PDPK1 -->|"regulates"| HOTAIR
    S6K["S6K"]
    PDPK1 -->|"activates"| S6K
    DNMT1["DNMT1"]
    PDPK1 -->|"regulates"| DNMT1
    Ms{"Ms"}
    PDPK1 -->|"expressed in"| Ms
    Schizophrenia{"Schizophrenia"}
    PDPK1 -->|"expressed in"| Schizophrenia
    PIK3C3["PIK3C3"]
    PDPK1 -->|"associated with"| PIK3C3
    LC3["LC3"]
    PDPK1 -->|"associated with"| LC3
    BCL2["BCL2"]
    BCL2 -->|"associated with"| PDPK1
    ATG14["ATG14"]
    ATG14 -->|"associated with"| PDPK1
    MTOR["MTOR"]
    MTOR -->|"associated with"| PDPK1
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| PDPK1
    BECN1["BECN1"]
    BECN1 -->|"associated with"| PDPK1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| PDPK1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| PDPK1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| PDPK1
    FOXO1["FOXO1"]
    FOXO1 -->|"expressed in"| PDPK1
    AKT -->|"activates"| PDPK1
    AKT1["AKT1"]
    AKT1 -->|"expressed in"| PDPK1
    style PDPK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
AKT	activates	protein	1.00
RSK2	activates	protein	0.80
HOTAIR	regulates	entity	0.80
FasL	activates	protein	0.80
SDC2	binds	protein	0.80
miR-1183	regulates	entity	0.80
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Mtor	activates	pathway	0.70
MTOR	activates	gene	0.70
S6K	activates	protein	0.70
DNMT1	regulates	gene	0.70
Schizophrenia	expressed_in	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Ms	expressed_in	disease	0.65
Infection	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
BCL2	associated_with	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
MAP1LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
Metastasis	activates	pathway	0.60
EIF4EBP1	activates	gene	0.60
TSC1	activates	gene	0.60
KDM6A	activates	gene	0.60
PI3K	activates	gene	0.60
EGFR	activates	gene	0.60
GBM	activates	gene	0.60
GLUD1	activates	gene	0.60
PI3K	expressed_in	gene	0.60
PIK3CA	expressed_in	gene	0.60
Apoptosis	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
TSC2	activates	gene	0.60
Mtor	associated_with	pathway	0.60
Glycolysis	activates	pathway	0.60
LC3	associated_with	gene	0.60
Insulin Signaling	activates	pathway	0.60
Akt	activates	pathway	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
CANCER	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Histone Modification	activates	pathway	0.60
PIK3C3	associated_with	gene	0.60

Incoming (21)

Source	Relation	Type	Str
KRAS	expressed_in	gene	0.60
BCL2	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AKT	expressed_in	gene	0.60
FOXO1	expressed_in	gene	0.60
AKT	activates	gene	0.60
AKT1	expressed_in	gene	0.60
PTEN	activates	gene	0.60
RPS6	activates	gene	0.60
RHEB	activates	gene	0.60
AKT1	activates	gene	0.60
RPS6KB1	activates	gene	0.60
HK2	activates	gene	0.60
LC3	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDPK1 in their description or question text

No additional research found