gene

NOXA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOXA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

27Outgoing

4Incoming

0Experiments

0Debates

Summary

NOXA is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with Aging, Als, Cancer. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOXA
Full Name	PMA-Induced mRNA 1
Chromosome	18q21.32.
Function	encodes a pro-apoptotic BH3-only protein of the BCL-2 family that plays a critical role in regulating mitochondrial apoptosis.
Molecular Weight	6.5 kDa
Amino Acids	103 aa
Pathways	pathway: BH3-Only Protein Function
UniProt ID	Q9Y2X9
NCBI Gene ID	5366
Ensembl ID	ENSG00000141682
OMIM	604958
GeneCards	NOXA
Human Protein Atlas	NOXA
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, ATF4, BAX, BCL-2, BCL2, CDK4
KG Connections	31 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NOXA — AlphaFold Q9Y2X9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NOXA["NOXA"]
    Parkinson{"Parkinson"}
    NOXA -->|"expressed in"| Parkinson
    Cancer{"Cancer"}
    NOXA -->|"activates"| Cancer
    BAX["BAX"]
    NOXA -->|"inhibits"| BAX
    PITX3["PITX3"]
    NOXA -->|"activates"| PITX3
    BCL2["BCL2"]
    NOXA -->|"activates"| BCL2
    Apoptosis(["Apoptosis"])
    NOXA -->|"inhibits"| Apoptosis
    APOPTOSIS["APOPTOSIS"]
    NOXA -->|"interacts with"| APOPTOSIS
    BCL_2["BCL-2"]
    NOXA -->|"interacts with"| BCL_2
    NOXA -->|"interacts with"| Apoptosis
    MDM2["MDM2"]
    NOXA -->|"activates"| MDM2
    NOXA -->|"activates"| APOPTOSIS
    CDK4["CDK4"]
    NOXA -->|"activates"| CDK4
    PROTEASOME_INHIBITION["PROTEASOME INHIBITION"]
    PROTEASOME_INHIBITION -->|"activates"| NOXA
    style NOXA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Parkinson	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Proteasome	activates	pathway	0.60
Unfolded Protein Response	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
MDM2	activates	gene	0.60
CDK4	activates	gene	0.60
ATF4	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CHOP	activates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
Mitophagy	therapeutic_target	pathway	0.60
BCL-2	interacts_with	gene	0.60
Apoptosis	interacts_with	pathway	0.60
CANCER	therapeutic_target	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
PUMA	activates	gene	0.60
DRP1	therapeutic_target	gene	0.60
BAX	inhibits	gene	0.60
PITX3	activates	gene	0.60
BCL2	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
BAX	activates	gene	0.60
PINK1	therapeutic_target	gene	0.60
PROTEASOME INHIBITION	activates	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOXA in their description or question text

No additional research found