gene

NR4A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR4A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

0Experiments

0Debates

Summary

NR4A2 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, activates, therapeutic target. Associated with ALS, Als, Atherosclerosis. Connected to 80 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NR4A2
Chromosome	2q22.1
Protein Type	Receptor
Function	It acts upstream of PITX3, LMX1A, and FOXA2 in the developmental cascade that generates dopaminergic neurons.
Primary Expression	ventricular and subventricular zones of the midbrain, where it specifies dopaminergic neuron fate
Amino Acids	598 aa
Exons	8
Pathways	Jak-Stat
Ensembl ID	ENSG00000153234
GeneCards	NR4A2
Human Protein Atlas	NR4A2
DNA-Binding Domain (DBD)	Two zinc finger motifs that recognize NGFI-B response elements (NBREs) and Nur response elements (NurREs)
Ligand-Binding Domain (LBD)	A hydrophobic cavity that, unlike classical nuclear receptors, does not bind traditional ligands but may interact with coactivators
AF-2 Domain	A transcriptional activation function region in the LBD required for coactivator recruitment
N-terminal Domain	Contains a transactivation function (AF-1) region with multiple phosphorylation sites
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, App, CANCER, CCL2, CD8, CX3CR1
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    NR4A2["NR4A2"] -->|"biomarker for"| Inflammation["Inflammation"]
    NR4A2["NR4A2"] -->|"biomarker for"| Als["Als"]
    NR4A2["NR4A2"] -->|"biomarker for"| Atherosclerosis["Atherosclerosis"]
    NR4A2["NR4A2"] -->|"biomarker for"| Ms["Ms"]
    NR4A2["NR4A2"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    NR4A2["NR4A2"] -->|"therapeutic target"| Diabetes["Diabetes"]
    NR4A2["NR4A2"] -->|"therapeutic target"| Ms["Ms"]
    NR4A2["NR4A2"] -->|"therapeutic target"| Inflammation["Inflammation"]
    NR4A2["NR4A2"] -->|"activates"| Ms["Ms"]
    NR4A2["NR4A2"] -->|"activates"| Cancer["Cancer"]
    NR4A2["NR4A2"] -.->|"inhibits"| Tumor["Tumor"]
    NR4A2["NR4A2"] -->|"therapeutic target"| Glioblastoma["Glioblastoma"]
    style NR4A2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Glioblastoma fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (67)

Target	Relation	Type	Str
ALS	biomarker_for	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Myocardial Infarction	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Cardiac	activates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Cardiovascular	activates	disease	0.65
CCL2	activates	gene	0.60
App	activates	protein	0.60
MITOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
EXOSOMES	activates	gene	0.60
Sphingolipid	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
INSULIN RESISTANCE	therapeutic_target	gene	0.60
App	biomarker_for	protein	0.60
CHOP	therapeutic_target	gene	0.60
NCOR1	activates	gene	0.60
NR4A1	activates	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
IL1A	biomarker_for	gene	0.60
LDLR	biomarker_for	gene	0.60
CX3CR1	activates	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
IL13RA1	biomarker_for	gene	0.60
Oxidative Stress	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Er Stress	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60

Incoming (36)

Source	Relation	Type	Str
IL1A	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
LDLR	biomarker_for	gene	0.60
JAK2	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
PTGS2	regulates	gene	0.60
AKT	therapeutic_target	gene	0.60
GABRA2	regulates	gene	0.60
STAT3	therapeutic_target	gene	0.60
JAK	regulates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PROINFLAMMATORY CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
IL-6	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
MICROGLIA	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CANCER	activates	gene	0.60
TNFRSF19	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
CCR9	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CD8	activates	gene	0.60
GBM	activates	gene	0.60
IL13RA1	biomarker_for	gene	0.60
MSR1	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
CSF2	associated_with	gene	0.50
MMP9	associated_with	gene	0.50
HTR3C	associated_with	gene	0.50
CXCL2	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NR4A2 in their description or question text

No additional research found