gene

SGK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

Summary

SGK1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Cardiac, Depression. Connected to 37 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SGK1
Chromosome	6q23
Protein Type	Kinase
Function	SGK1 is a member of the AGC kinase family (PKA/PKB/PKC-related) with diverse cellular functions: [@firestone2003]
Molecular Weight	49 kDa
Amino Acids	433 aa
Exons	13
Pathways	mTOR, mtor
GeneCards	SGK1
Human Protein Atlas	SGK1
SGK1 isoform 1	Full-length protein (433 amino acids)
SGK1 isoform 2	Truncated variant with alternative start site
SGK1 isoform 3	Tissue-specific expression pattern
Associated Diseases	Als, Depression, Inflammation, Lymphoma, Ms
Interactions	AND, BDNF, CD4, CREB, CYTOKINES, DNA
KG Connections	69 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SGK1 Gene

gene · 993 words

→

SGK1 Protein

protein · 732 words

→

Pathway Diagram

graph TD
    SGK1["SGK1"]
    Als{"Als"}
    SGK1 -->|"associated with"| Als
    Ms{"Ms"}
    SGK1 -->|"associated with"| Ms
    Depression{"Depression"}
    SGK1 -->|"associated with"| Depression
    Inflammation{"Inflammation"}
    SGK1 -->|"associated with"| Inflammation
    Lymphoma{"Lymphoma"}
    SGK1 -->|"associated with"| Lymphoma
    SGK1 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    SGK1 -->|"therapeutic target"| Tumor
    FKBP5["FKBP5"]
    SGK1 -->|"associated with"| FKBP5
    A2M["A2M"]
    SGK1 -->|"associated with"| A2M
    AQP4["AQP4"]
    SGK1 -->|"associated with"| AQP4
    TNF["TNF"]
    SGK1 -->|"associated with"| TNF
    P2RX7["P2RX7"]
    SGK1 -->|"associated with"| P2RX7
    BCL2["BCL2"]
    BCL2 -->|"associated with"| SGK1
    TP53["TP53"]
    TP53 -->|"therapeutic target"| SGK1
    TET2["TET2"]
    TET2 -->|"associated with"| SGK1
    style SGK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
HDAC6	upregulates	gene	0.90
Cellular Stress	associated_with	process	0.85
Tau	phosphorylates	protein	0.85
Alzheimer's Disease	biomarker_for	disease	0.82
Cardiac	activates	disease	0.65
Heart Failure	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Als	activates	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Autoimmune	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	associated_with	disease	0.65
Notch	associated_with	pathway	0.60
GENES	activates	gene	0.60
TNF-Α	activates	gene	0.60
BDNF	activates	gene	0.60
Jnk	expressed_in	protein	0.60
neuroinflammation	activates	disease	0.60
microglia	expressed_in	cell_type	0.60
epigenetic regulation	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
MYD88	associated_with	gene	0.60
SOCS1	associated_with	gene	0.60
NOTCH2	associated_with	gene	0.60
NOTCH1	therapeutic_target	gene	0.60
CHOP	therapeutic_target	gene	0.60
NFAT5	activates	gene	0.60
TNF	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mapk	activates	pathway	0.60
Tgf-Β	activates	pathway	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
USP18	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
SOD2	inhibits	gene	0.60
Actin	expressed_in	protein	0.60
FKBP5	associated_with	gene	0.60

Incoming (18)

Source	Relation	Type	Str
CD4	activates	gene	0.60
BCL2	associated_with	gene	0.60
TP53	therapeutic_target	gene	0.60
TET2	associated_with	gene	0.60
NCOR1	activates	gene	0.60
ITGA3	activates	gene	0.60
RNA	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
CREB	activates	gene	0.60
PS1	associated_with	gene	0.60
HDAC6	activates	gene	0.60
HDAC6	inhibits	gene	0.60
HDAC6	targets	gene	0.60
APP	associated_with	gene	0.60
AND	activates	gene	0.60
CYTOKINES	activates	gene	0.60
MAPK	activates	gene	0.60
ERK1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SGK1 in their description or question text

No additional research found