gene

CASP7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

5Outgoing

2Incoming

0Experiments

0Debates

Summary

CASP7 - executioner caspase in apoptosis and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CASP7
Chromosome	10q25.3
Protein Type	Protease
Function	is an executioner (effector) caspase that plays a critical role in the execution phase of apoptosis.
Primary Expression	most tissues, including the brain
Molecular Weight	35 kDa
Amino Acids	303 aa
Exons	8
UniProt ID	P55210
NCBI Gene ID	840
GeneCards	CASP7
Human Protein Atlas	CASP7
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CASP7 — AlphaFold P55210 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CASP7 Gene

gene · 1147 words

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Pathway Diagram

flowchart TD
    N0["CASP7"]
    N1["BCL2"]
    N1 -->|"regulates"| N0
    N2["CASP1"]
    N2 -->|"regulates"| N0
    N3["CASP8"]
    N0 -->|"regulates"| N3
    N4["MCL1"]
    N0 -->|"regulates"| N4
    N5["P53"]
    N0 -->|"regulates"| N5
    N6["TNF"]
    N0 -->|"regulates"| N6
    N7["schizophrenia"]
    N0 -->|"regulates"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
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    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 disease

Outgoing (5)

Target	Relation	Type	Str
P53	regulates	gene	0.60
CASP8	regulates	gene	0.60
MCL1	regulates	gene	0.60
TNF	regulates	gene	0.60
schizophrenia	regulates	disease	0.60

Incoming (2)

Source	Relation	Type	Str
BCL2	regulates	gene	0.60
CASP1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASP7 in their description or question text

No additional research found