| Gene Symbol | CASP8 |
| Full Name | Caspase 8 |
| Aliases | CASP8PROTEIN |
| Chromosome | 2q33 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </td><td>Cytoplasm, plasma membrane (DISC)</td></tr> |
| Molecular Weight | 20 kDa |
| Amino Acids | 80 aa |
| Pathways | Akt, Nf-Κb, Pi3K, Toll-Like Receptor |
| UniProt ID | [Q14790](https://www.uniprot.org/uniprot/Q14790) |
| Ensembl ID | ENSG00000164040 |
| GeneCards | CASP8 |
| Human Protein Atlas | CASP8 |
| PARP | Cleavage of poly(ADP-ribose) polymerase inactivates DNA repair, committing the cell to death |
| Structural proteins | Lamin A/C, actin, beta-catenin — dismantling of cellular architecture |
| Associated Diseases | Als, Autoimmune, Ms, Rheumatoid Arthritis |
| Known Drugs/Compounds | natural products |
| Interactions | Actin, AKT1, AND, APOPTOSIS, CANCER, CASP3 |
| KG Connections | 177 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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