gene

CASP9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

CASP9 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, contributes to. Associated with ALS, Als, Leukemia. Connected to 70 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CASP9
Chromosome	1p36.21
Protein Type	Protease
Function	is a member of the cysteine-aspartic acid protease (caspase) family.
Amino Acids	461 aa
Gene Type	Protein coding
Pathways	Akt, Nf-Κb, Pi3K, Toll-Like Receptor
UniProt ID	P55211
Ensembl ID	ENSG00000132906
GeneCards	CASP9
Human Protein Atlas	CASP9
Prodomain	N-terminal CARD (Caspase Recruitment Domain) for apoptosome interaction
Large Subunit (p35)	Contains the catalytic cysteine residue
Small Subunit (p12)	Completes the active site
Phosphorylation	Ser196 phosphorylation by Akt inhibits caspase-9 activity
Associated Diseases	neurodegeneration
Known Drugs/Compounds	Bpmc
Interactions	AKT, Anti-recoverin Antibodies, APOPTOSIS, ATM, EIF2A, GALT
KG Connections	89 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CASP9 — AlphaFold P55211 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CASP9 (Caspase 9)

gene · 2534 words

→

Pathway Diagram

flowchart TD
    CASP9["CASP9"] -->|"encodes"| CASPASE9["CASPASE9"]
    CASP9["CASP9"] -->|"activates"| Ms["Ms"]
    CASP9["CASP9"] -->|"activates"| Als["Als"]
    CASP9["CASP9"] -->|"contributes to"| Als["Als"]
    CASP9["CASP9"] -->|"regulates"| Lymphoma["Lymphoma"]
    CASP9["CASP9"] -->|"therapeutic target"| Ms["Ms"]
    CASP9["CASP9"] -->|"regulates"| Tumor["Tumor"]
    CASP9["CASP9"] -->|"regulates"| Leukemia["Leukemia"]
    CASP9["CASP9"] -->|"activates"| ALS["ALS"]
    CASP9["CASP9"] -->|"activates"| apoptosis["apoptosis"]
    CASP9["CASP9"] -->|"activates"| PTEN["PTEN"]
    CASP9["CASP9"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    style CASP9 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CASPASE9 fill:#006494,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Lymphoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Leukemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style apoptosis fill:#006494,stroke:#333,color:#e0e0e0
    style PTEN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#333,color:#e0e0e0

Outgoing (66)

Target	Relation	Type	Str
Apoptosis	involved_in	process	0.90
follicular atresia	promotes	process	0.85
Follicular Atresia	contributes_to	process	0.80
CASPASE9	encodes	protein	0.80
Ms	activates	disease	0.65
Als	activates	disease	0.65
Lymphoma	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Leukemia	regulates	disease	0.65
Als	contributes_to	disease	0.65
ALS	activates	disease	0.65
apoptosis	activates	phenotype	0.64
CASP4	biomarker_for	gene	0.60
Rb	associated_with	protein	0.60
Oxidative Stress	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
Pi3K	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
OXIDATIVE STRESS	activates	gene	0.60
RNA	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Akt	activates	pathway	0.60
GALT	activates	gene	0.60
ATM	activates	gene	0.60
EIF2A	activates	gene	0.60
CASP3	biomarker_for	gene	0.60
IL6	biomarker_for	gene	0.60
JUN	regulates	gene	0.60
BCL2L1	regulates	gene	0.60
RELA	regulates	gene	0.60
CASP3	regulates	gene	0.60
HSP90AA1	regulates	gene	0.60
STAT1	regulates	gene	0.60
MCL1	regulates	gene	0.60
RAGE	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
NF-ΚB	regulates	gene	0.60
P53	regulates	gene	0.60
Toll-Like Receptor	regulates	pathway	0.60
Akt	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Pi3K	regulates	pathway	0.60
PTEN	activates	gene	0.60
AKT	activates	gene	0.60
CASP8	regulates	gene	0.60
AKT	regulates	gene	0.60
STAT3	regulates	gene	0.60
DNA	expressed_in	gene	0.60

Incoming (23)

Source	Relation	Type	Str
Bpmc	activates	compound	0.90
Anti-recoverin Antibodies	activates	protein	0.80
GENES	activates	gene	0.60
DNA	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
PTEN	activates	gene	0.60
PI3K	activates	gene	0.60
BCL2	regulates	gene	0.60
TP53	regulates	gene	0.60
TLR4	regulates	gene	0.60
PI3K	regulates	gene	0.60
TNF	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
GALT	activates	gene	0.60
ATM	activates	gene	0.60
EIF2A	activates	gene	0.60
AKT	contributes_to	gene	0.60
ATM	contributes_to	gene	0.60
RNA	activates	gene	0.60
AKT	activates	gene	0.60
Autophagy	activates	process	0.50
AUTOPHAGY	co_discussed	process	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASP9 in their description or question text

No additional research found