protein

TNFR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

387Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TNFR1 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Aging, Als. Connected to 108 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	TNF Receptor Superfamily Member 1A
Aliases	TNFRSF1A (TNFR1)
Chromosome	12p13.31
Protein Type	Receptor
Function	is a member of the tumor necrosis factor receptor superfamily.
Molecular Weight	55 kDa
Amino Acids	455 aa
Exons	10
Pathways	NF-κB, MAPK pathway
UniProt ID	P19438
NCBI Gene ID	7132
Associated Diseases	ALS, Alzheimer, Neurodegeneration, Neuroinflammation, Parkinson
Interactions	Actin, ALS, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, ANXIETY
KG Connections	387 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFR1 — AlphaFold P19438 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFR1["TNFR1"] -->|"regulates"| Tumor["Tumor"]
    TNFR1["TNFR1"] -->|"expressed in"| Als["Als"]
    TNFR1["TNFR1"] -->|"regulates"| Leukemia["Leukemia"]
    TNFR1["TNFR1"] -->|"activates"| Cancer["Cancer"]
    TNFR1["TNFR1"] -->|"regulates"| Als_1["Als"]
    TNFR1["TNFR1"] -->|"regulates"| Lymphoma["Lymphoma"]
    TNF["TNF"] -->|"interacts"| TNFR1["TNFR1"]
    GFAP["GFAP"] -->|"regulates"| TNFR1["TNFR1"]
    TNF_2["TNF"] -->|"expressed in"| TNFR1["TNFR1"]
    TNFR2["TNFR2"] -->|"expressed in"| TNFR1["TNFR1"]
    style TNFR1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (266)

Target	Relation	Type	Str
pro-inflammatory processes	promotes	process	0.90
cytotoxic signaling	activates	process	0.90
neuroinflammation	mediates	process	0.90
astrocyte death	mediates	process	0.85
intestinal epithelial cell	internalization	cell_type	0.80
apoptosis pathway	participates_in	pathway	0.80
tmTNF	binds_to	protein	0.80
necroptosis	participates_in	pathway	0.80
CASP1	activates	gene	0.80
solTNF	binds_to	protein	0.80
most cell types	expressed_in	cell_type	0.80
Tumor	regulates	disease	0.75
Inflammation	activates	disease	0.75
necroptosis	regulates	process	0.70
TNF-Α	activates	gene	0.70
NF-kB signaling	participates_in	pathway	0.70
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
Necroptosis	regulates	disease	0.65
Alzheimer	protects_against	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Psoriasis	activates	disease	0.65
Als	expressed_in	disease	0.65
Leukemia	regulates	disease	0.65
Ms	inhibits	disease	0.65
Stroke	activates	disease	0.65
ALS	protects_against	disease	0.65
Infection	activates	disease	0.65
Als	activates	disease	0.65
Depression	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Anxiety	activates	disease	0.65
Ms	regulates	disease	0.65
Als	protects_against	disease	0.65
Tumor	protects_against	disease	0.65
Ms	protects_against	disease	0.65
Autoimmune	inhibits	disease	0.65
Rheumatoid Arthritis	inhibits	disease	0.65
Infection	protects_against	disease	0.65
Aging	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Lymphoma	regulates	disease	0.65

Incoming (121)

Source	Relation	Type	Str
TNF-α	binds_to	protein	0.95
CASP8	interacts_with	gene	0.85
EFHD2	interacts_with	gene	0.80
TNF	binds	gene	0.80
INFLAMMATION	activates	gene	0.70
TNF	interacts_with	protein	0.70
EPILEPSY	associated_with	gene	0.70
TNF	inhibits	gene	0.60
HMGB1	inhibits	gene	0.60
TNFR2	causes	gene	0.60
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NF-ΚB	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
RB1CC1	regulates	gene	0.60
SLC7A11	activates	gene	0.60
TNFR2	interacts_with	gene	0.60
TNF	activates	gene	0.60
STAT1	activates	gene	0.60
LC3	protects_against	gene	0.60
ROS	activates	gene	0.60
RNA	expressed_in	gene	0.60
GFAP	regulates	gene	0.60
TNF	expressed_in	gene	0.60
TNFR2	expressed_in	gene	0.60
CD19	regulates	gene	0.60
BECN1	regulates	gene	0.60
RIPK1	interacts_with	gene	0.60
GAIN	regulates	gene	0.60
TNFRSF1A	interacts_with	gene	0.60
TRADD	regulates	gene	0.60
COFILIN	inhibits	gene	0.60
TNF	regulates	gene	0.60
BDNF	associated_with	gene	0.60
FAS	expressed_in	gene	0.60
GENES	regulates	gene	0.60
TNF	causes	gene	0.60
FIP200	protects_against	gene	0.60
ATG9A	protects_against	gene	0.60
NF-ΚB	regulates	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
RUBCNL	interacts_with	gene	0.60
RIPK1	regulates	gene	0.60
RIPK3	activates	gene	0.60
KMT2B	inhibits	entity	0.60
TNF	upregulates	entity	0.60
CCL2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFR1 in their description or question text

No additional research found