concept

IL8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

194Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IL8 is a concept in neurodegeneration research. Key relationships include: expressed in, activates, therapeutic target. Associated with Als, Breast Cancer, Cancer. Connected to 102 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IL8
Key Genes/Proteins	ABCB1, ABCG2, ACTB, AKT, AKT1, ALZHEIMER
Related Diseases	Als, Alzheimer
Related Pathways	Akt, Angiogenesis

Pathway Diagram

graph TD
    IL8["IL8"]
    IL8 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL8 -->|"expressed in"| Als["Als"]
    IL8 -->|"activates"| Epilepsy["Epilepsy"]
    IL8 -->|"activates"| Ms["Ms"]
    IL8 -->|"expressed in"| Innate_Immunity["Innate Immunity"]
    IL8 -->|"expressed in"| Toll_Like_Receptor["Toll-Like Receptor"]
    IL8 -->|"expressed in"| Immune_Response["Immune Response"]
    IL8 -->|"expressed in"| DICER1["DICER1"]
    IL8 -->|"expressed in"| NR3C1["NR3C1"]
    IL8 -->|"expressed in"| IL1B["IL1B"]
    hyperoxia["hyperoxia"] -->|"contributes to"| IL8
    TNF["TNF"] -->|"activates"| IL8
    NFKB1["NFKB1"] -->|"activates"| IL8
    TPM2["TPM2"] -->|"regulates"| IL8
    NFKB["NFKB"] -->|"regulates"| IL8
    DUPILUMAB["DUPILUMAB"] -->|"inhibits"| IL8
    GAL["GAL"] -->|"activates"| IL8
    CYTOKINES["CYTOKINES"] -->|"expressed in"| IL8
    TLR2["TLR2"] -->|"expressed in"| IL8
    OCLN["OCLN"] -->|"expressed in"| IL8

Outgoing (103)

Target	Relation	Type	Str
Immune Aging	modulates	process	0.85
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.85
Tumor	therapeutic_target	disease	0.75
INFLAMMATION	activates	phenotype	0.72
muscle wasting	associated_with	phenotype	0.70
Obesity	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Epilepsy	activates	disease	0.65
Ms	activates	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Angiogenesis	activates	pathway	0.60
CYTOKINES	therapeutic_target	gene	0.60
TNFA	therapeutic_target	gene	0.60
Mtor	activates	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Stem Cell	activates	pathway	0.60
Rb	inhibits	protein	0.60
Nf-Kb	activates	pathway	0.60
JUNB	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
IL6	inhibits	gene	0.60
COL1A1	inhibits	gene	0.60
CCL2	inhibits	gene	0.60
TNF	inhibits	gene	0.60
Inflammasome	inhibits	pathway	0.60
CYTOKINES	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
diabetes	activates	disease	0.60
MMP1	activates	gene	0.60
MMP3	activates	gene	0.60
JUN	inhibits	gene	0.60
Nlrp3 Inflammasome	inhibits	pathway	0.60
IL6	expressed_in	gene	0.60
ANG	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60

Incoming (91)

Source	Relation	Type	Str
NFKB	upregulates	protein	0.90
hyperoxia	contributes_to	phenotype	0.90
TNF	activates	protein	0.90
NFKB1	activates	gene	0.80
TPM2	regulates	gene	0.80
DUPILUMAB	inhibits	drug	0.72
NFKB	regulates	protein	0.72
INFLAMMATION	inhibits	gene	0.60
S100A9	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
IL18	inhibits	gene	0.60
NLRP1	inhibits	gene	0.60
AND	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
IL1B	inhibits	gene	0.60
GENES	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
IL6	expressed_in	gene	0.60
S100A8	inhibits	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
FGF21	activates	gene	0.60
ABCB1	activates	gene	0.60
ABCG2	activates	gene	0.60
CLDN5	activates	gene	0.60
BCL2L1	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CXCL8	regulates	gene	0.60
IL6	regulates	gene	0.60
RAB7A	regulates	gene	0.60
IL1B	regulates	gene	0.60
CD8	regulates	gene	0.60
EGFR	regulates	gene	0.60
HSP90AA1	regulates	gene	0.60
ACTB	regulates	gene	0.60
IFIH1	regulates	gene	0.60
ISG15	regulates	gene	0.60
MMP2	regulates	gene	0.60
IL6	associated_with	gene	0.60
IL3	inhibits	gene	0.60
CAMKII	inhibits	gene	0.60
CCND1	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
GNAL	inhibits	gene	0.60
IL6	inhibits	gene	0.60
IL6	activates	gene	0.60
TNF	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL8 in their description or question text

No additional research found