gene

CXCL8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

487Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CXCL8 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 164 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCL8
Chromosome	4q13.3
Protein Family	CXC chemokine family (ELR+)
Function	is a protein encoded by the CXCL8 gene.
Primary Expression	the central nervous system, influencing neurotransmitter release and synaptic plasticity[@biber2002]
Subcellular Localization	Secreted, extracellular
Molecular Weight	8 kDa
Amino Acids	99 aa
Exons	4
Pathways	NF-κB
UniProt ID	[P10145](https://www.uniprot.org/uniprot/P10145)
NCBI Gene ID	3576
GeneCards	CXCL8
Human Protein Atlas	CXCL8
NF-κB sites	Critical for cytokine-induced expression
Associated Diseases	ALS, Alzheimer, Depression, Fibrosis, Inflammation, Ms
Known Drugs/Compounds	rapamycin
Interactions	Actin, adcy2, ADCY2, AGING, AKT, ALZHEIMER
KG Connections	487 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

cxcl8

gene · 1826 words

→

CXCL8 Protein

protein · 1183 words

→

Pathway Diagram

graph TD
    CXCL8["CXCL8"]
    CXCL8 -->|"expressed in"| Tumor["Tumor"]
    CXCL8 -->|"target for"| Stroke["Stroke"]
    CXCL8 -->|"target for"| Ms["Ms"]
    CXCL8 -->|"target for"| Cardiovascular["Cardiovascular"]
    CXCL8 -->|"target for"| Atherosclerosis["Atherosclerosis"]
    CXCL8 -->|"activates"| Fibrosis["Fibrosis"]
    CXCL8 -->|"activates"| Inflammation["Inflammation"]
    CXCL8 -->|"regulates"| Senescence["Senescence"]
    IL1B["IL1B"] -->|"regulates"| CXCL8
    TLR2["TLR2"] -->|"regulates"| CXCL8
    CXCL1["CXCL1"] -->|"regulates"| CXCL8
    JUN["JUN"] -->|"regulates"| CXCL8
    MMP9["MMP9"] -->|"regulates"| CXCL8
    TNF["TNF"] -->|"regulates"| CXCL8
    GENES["GENES"] -->|"regulates"| CXCL8
    CCL3["CCL3"] -->|"regulates"| CXCL8

Outgoing (308)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Tumor	expressed_in	disease	0.85
Inflammation	regulates	disease	0.75
Cancer	activates	disease	0.75
CCL5	associated_with	gene	0.70
CANCER	activates	gene	0.70
Angiogenesis	activates	pathway	0.70
Mapk	activates	pathway	0.70
Atherosclerosis	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Senescence	regulates	disease	0.65
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Autism	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Neuropathy	biomarker_for	disease	0.65
Als	contributes_to	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Senescence	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
Fibrosis	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	biomarker_for	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Depression	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Depression	causes	disease	0.65
Tumor	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
ALZHEIMER	interacts_with	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
SIRT1	associated_with	gene	0.60

Incoming (179)

Source	Relation	Type	Str
SNCA	alters	gene	0.80
AΒ1-42	alters	compound	0.80
INFLAMMATION	activates	gene	0.80
MACROPHAGES	interacts_with	cell_type	0.70
AKT1	targets	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
WNT	activates	gene	0.60
P21	activates	gene	0.60
IL-1	activates	gene	0.60
rapamycin	targets	drug	0.60
CCL2	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
CCL3	regulates	gene	0.60
NFL	regulates	gene	0.60
GFAP	regulates	gene	0.60
CDKN1A	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
AKT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
GAL	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
S100A9	contributes_to	gene	0.60
S100A8	contributes_to	gene	0.60
SIRT1	therapeutic_target	gene	0.60
TLR4	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
IL10	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
VIM	associated_with	gene	0.60
IL6	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
CS	activates	gene	0.60
CXCL1	activates	gene	0.60
CCL5	associated_with	gene	0.60
CSF2	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
ROS	activates	gene	0.60
HIF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CXCL8 in their description or question text

No additional research found