gene

IRAK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRAK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

11Outgoing

7Incoming

0Experiments

0Debates

Summary

IRAK2 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, implicated in. Associated with Epilepsy, Ms. Connected to 19 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IRAK2
Full Name	Interleukin-1 Receptor-Associated Kinase 2
Chromosome	3p25.3
Protein Family	IRAK family (IRAK2)
Protein Type	Kinase
Function	Receptor activation: Upon TLR or IL-1R activation by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), IRAK2 is recruited to the receptor complex through
Pathways	NF-κB, MAPK
UniProt ID	O43187
NCBI Gene ID	3656
Ensembl ID	ENSG00000134070
GeneCards	IRAK2
Human Protein Atlas	IRAK2
Residual kinase activity	Low but detectable autophosphorylation capability
Scaffolding function	Primary role is as a scaffold for complex assembly
Activation loop	Contains an activation loop that can be phosphorylated
Associated Diseases	neurodegeneration
Interactions	IL1B, IL8
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IRAK2 — AlphaFold O43187 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IRAK2

gene · 1082 words

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Pathway Diagram

graph TD
    IRAK2["IRAK2"]
    Epilepsy{"Epilepsy"}
    IRAK2 -->|"activates"| Epilepsy
    Ms{"Ms"}
    IRAK2 -->|"activates"| Ms
    IL10["IL10"]
    IRAK2 -->|"expressed in"| IL10
    IRAK1["IRAK1"]
    IRAK2 -->|"expressed in"| IRAK1
    IKBKG["IKBKG"]
    IRAK2 -->|"expressed in"| IKBKG
    TLR2["TLR2"]
    IRAK2 -->|"expressed in"| TLR2
    TLR1["TLR1"]
    IRAK2 -->|"expressed in"| TLR1
    HMGB1["HMGB1"]
    IRAK2 -->|"expressed in"| HMGB1
    IKBKB["IKBKB"]
    IRAK2 -->|"expressed in"| IKBKB
    IL8["IL8"]
    IRAK2 -->|"activates"| IL8
    Nf__b(["Nf-Kappab"])
    IRAK2 -->|"expressed in"| Nf__b
    neurodegeneration["neurodegeneration"]
    IRAK2 -->|"implicated in"| neurodegeneration
    TLR4["TLR4"]
    TLR4 -->|"expressed in"| IRAK2
    IL1B["IL1B"]
    IL1B -->|"activates"| IRAK2
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"expressed in"| IRAK2
    TLR3["TLR3"]
    TLR3 -->|"expressed in"| IRAK2
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    PROINFLAMMATORY_CYTOKINES -->|"expressed in"| IRAK2
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| IRAK2
    RAGE["RAGE"]
    RAGE -->|"expressed in"| IRAK2
    style IRAK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Epilepsy	activates	disease	0.65
Ms	activates	disease	0.65
IL8	activates	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
IL10	expressed_in	gene	0.60
IRAK1	expressed_in	gene	0.60
IKBKG	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
TLR1	expressed_in	gene	0.60
HMGB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60

Incoming (7)

Source	Relation	Type	Str
CYTOKINES	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
IL1B	activates	gene	0.60
TLR3	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRAK2 in their description or question text

No additional research found