gene

IKBKG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IKBKG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

27Outgoing

18Incoming

0Experiments

0Debates

Summary

IKBKG (IκB Kinase Gamma/NEMO) encodes the regulatory subunit of the IKK complex, essential for NF-κB activation. Critical for neuroinflammation in Alzheimer's and Parkinson's disease, immune responses, and cell survival. Mutations cause Incontinentia Pigmenti and immunodeficiency syndromes.

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🧬 Gene Info

Gene Symbol	IKBKG
Full Name	IκB Kinase Gamma / NEMO
Aliases	IκB Kinase Gamma/NEMO
Chromosome	Xq28
Protein Type	Kinase
Function	encodes a critical regulatory subunit of the IκB kinase (IKK) complex.
Molecular Weight	48 kDa
Amino Acids	419 aa
Pathways	NF-κB, NF-κB signaling
UniProt ID	[Q9Y6K9](https://www.uniprot.org/uniprot/Q9Y6K9)
Ensembl ID	ENSG00000265203
GeneCards	IKBKG
Human Protein Atlas	IKBKG
IKKα (IKBKΑ)	IKK1, a serine/threonine kinase with nuclear functions
IKKβ (IKBKB)	IKK2, the primary kinase for NF-κB activation
Associated Diseases	neurodegeneration
Known Drugs/Compounds	Polyphenols
Interactions	IKBKB, INFLAMMATION, LYSOSOME, NEMO, NFKB, OTULIN
KG Connections	44 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IKBKG Gene

gene · 1949 words

→

IKBKG Protein

protein · 774 words

→

Pathway Diagram

graph TD
    IKBKG["IKBKG"]
    Inflammation{"Inflammation"}
    IKBKG -->|"activates"| Inflammation
    Als{"Als"}
    IKBKG -->|"activates"| Als
    IKBKG -->|"regulates"| Als
    Ms{"Ms"}
    IKBKG -->|"regulates"| Ms
    Epilepsy{"Epilepsy"}
    IKBKG -->|"expressed in"| Epilepsy
    IKBKG -->|"expressed in"| Ms
    Lysosomal_Degradation(["Lysosomal Degradation"])
    IKBKG -->|"activates"| Lysosomal_Degradation
    PSMB8["PSMB8"]
    IKBKG -->|"regulates"| PSMB8
    Nf__b(["Nf-Kappab"])
    IKBKG -->|"activates"| Nf__b
    TLR2["TLR2"]
    IKBKG -->|"expressed in"| TLR2
    TLR1["TLR1"]
    IKBKG -->|"expressed in"| TLR1
    HMGB1["HMGB1"]
    IKBKG -->|"expressed in"| HMGB1
    OTULIN["OTULIN"]
    OTULIN -->|"activates"| IKBKG
    NFKB["NFKB"]
    NFKB -->|"activates"| IKBKG
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"regulates"| IKBKG
    TREX1["TREX1"]
    TREX1 -->|"regulates"| IKBKG
    TLR4["TLR4"]
    TLR4 -->|"expressed in"| IKBKG
    IL1B["IL1B"]
    IL1B -->|"expressed in"| IKBKG
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"expressed in"| IKBKG
    TLR3["TLR3"]
    TLR3 -->|"expressed in"| IKBKG
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    PROINFLAMMATORY_CYTOKINES -->|"expressed in"| IKBKG
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| IKBKG
    RAGE["RAGE"]
    RAGE -->|"expressed in"| IKBKG
    IRAK2["IRAK2"]
    IRAK2 -->|"expressed in"| IKBKG
    style IKBKG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
IKBKB	interacts_with	protein	0.90
RELA	phosphorylates	gene	0.90
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	regulates	disease	0.65
Epilepsy	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Ms	regulates	disease	0.65
NFKB	activates	gene	0.60
LYSOSOME	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
Stem Cell	activates	pathway	0.60
PAP	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
HMGB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
OTULIN	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
NEMO	regulates	gene	0.60
NEMO	activates	gene	0.60
Lysosomal Degradation	activates	pathway	0.60
PSMB8	regulates	gene	0.60
IL8	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
TLR1	expressed_in	gene	0.60

Incoming (18)

Source	Relation	Type	Str
ROS	activates	process	0.95
NEMO	associated_with	protein	0.90
TNF	activates	gene	0.90
Polyphenols	inhibits	compound	0.80
TREX1	regulates	gene	0.60
TLR4	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
TLR3	expressed_in	gene	0.60
SAMHD1	regulates	gene	0.60
IRAK2	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
IRAK1	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
OTULIN	activates	gene	0.60
NFKB	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IKBKG in their description or question text

No additional research found