gene

IRAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

49Outgoing

26Incoming

0Experiments

0Debates

Summary

IRAK1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, expressed in, implicated in. Associated with Als, Cancer, Epilepsy. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IRAK1
Protein Family	IL-1 receptor-associated kinases
Protein Type	Serine/Threonine Kinase
Function	IRAK1 is a serine/threonine kinase recruited to activated TLR/IL-1R complexes via MyD88.
Molecular Weight	77 kDa
Amino Acids	712 aa
Pathways	NF-κB, MAPK pathway, MAPK, NF-κB pathway
UniProt ID	[P51617](https://www.uniprot.org/uniprot/P51617)
GeneCards	IRAK1
Human Protein Atlas	IRAK1
N-terminal Death Domain (DD)	Mediates interactions with MyD88 and other adaptor proteins
ProST domain	Proline-rich region involved in protein-protein interactions
Kinase Domain (KD)	Catalytic domain with serine/threonine kinase activity
C-terminal domain	Regulatory region controlling kinase activity
Phosphorylation	Autophosphorylation at multiple serine/threonine residues (Thr387, Ser376) activates the kinase
Associated Diseases	neurodegeneration
Interactions	AKT, ASC, ASK1, ATF3, ATG5, CCR2
KG Connections	75 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IRAK1 Gene

gene · 1018 words

→

IRAK1 Protein

protein · 621 words

→

Pathway Diagram

graph TD
    IRAK1["IRAK1"]
    Epilepsy{"Epilepsy"}
    IRAK1 -->|"expressed in"| Epilepsy
    Ms{"Ms"}
    IRAK1 -->|"expressed in"| Ms
    Als{"Als"}
    IRAK1 -->|"expressed in"| Als
    IKBKG["IKBKG"]
    IRAK1 -->|"expressed in"| IKBKG
    TLR2["TLR2"]
    IRAK1 -->|"expressed in"| TLR2
    TLR1["TLR1"]
    IRAK1 -->|"expressed in"| TLR1
    HMGB1["HMGB1"]
    IRAK1 -->|"expressed in"| HMGB1
    IKBKB["IKBKB"]
    IRAK1 -->|"expressed in"| IKBKB
    IL8["IL8"]
    IRAK1 -->|"expressed in"| IL8
    Nf__b(["Nf-Kappab"])
    IRAK1 -->|"expressed in"| Nf__b
    Complement(["Complement"])
    IRAK1 -->|"expressed in"| Complement
    neurodegeneration["neurodegeneration"]
    IRAK1 -->|"implicated in"| neurodegeneration
    TLR4["TLR4"]
    TLR4 -->|"expressed in"| IRAK1
    IL1B["IL1B"]
    IL1B -->|"expressed in"| IRAK1
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"expressed in"| IRAK1
    TLR3["TLR3"]
    TLR3 -->|"expressed in"| IRAK1
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    PROINFLAMMATORY_CYTOKINES -->|"expressed in"| IRAK1
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| IRAK1
    RAGE["RAGE"]
    RAGE -->|"expressed in"| IRAK1
    IRAK2["IRAK2"]
    IRAK2 -->|"expressed in"| IRAK1
    IL10["IL10"]
    IL10 -->|"expressed in"| IRAK1
    TRAF6["TRAF6"]
    TRAF6 -->|"activates"| IRAK1
    style IRAK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (49)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Epilepsy	expressed_in	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
TLR2	expressed_in	gene	0.60
TLR1	expressed_in	gene	0.60
HMGB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
PI3K	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
XIAP	therapeutic_target	gene	0.60
TRAF6	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
ISG15	activates	gene	0.60
JNK	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3	activates	gene	0.60
MLKL	activates	gene	0.60
NLRP3	activates	gene	0.60
NMDAR	activates	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
BCL-2	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Microrna	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
IKBKG	expressed_in	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
RNA	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
IL8	expressed_in	gene	0.60
Complement	expressed_in	pathway	0.60
Il-1	activates	protein	0.60
IL1R1	regulates	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
Immune Response	regulates	pathway	0.60
RAGE	activates	gene	0.55
NF-kB signaling	participates_in	pathway	0.55

Incoming (26)

Source	Relation	Type	Str
AKT	activates	gene	0.60
ASC	activates	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60
CCR2	activates	gene	0.60
CHOP	activates	gene	0.60
IL-1	activates	gene	0.60
CYTOKINES	regulates	gene	0.60
ASK1	activates	gene	0.60
ERK	activates	gene	0.60
IFN	activates	gene	0.60
TLR4	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
TLR3	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
IRAK2	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
PTEN	therapeutic_target	gene	0.60
TOLLIP	activates	gene	0.60
TRAF6	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
KRAS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRAK1 in their description or question text

No additional research found