gene

TLR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

26Outgoing

22Incoming

0Experiments

0Debates

Summary

TLR1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, interacts with. Associated with Als, Epilepsy, Inflammation. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TLR1
Full Name	Toll-Like Receptor 1
Chromosome	4p14
Protein Type	Receptor
Primary Expression	microglia and contributes to neuroinflammatory processes in neurodegenerative diseases
Molecular Weight	90 kDa
Amino Acids	799 aa
Pathways	NF-κB, MAPK, MAPK pathway
UniProt ID	Q9Y5S2
NCBI Gene ID	7099
Ensembl ID	ENSG00000174125
OMIM	601194
GeneCards	TLR1
Human Protein Atlas	TLR1
Pattern recognition receptor	Detects microbial-associated molecular patterns (MAMPs)
Associated Diseases	neurodegeneration
Interactions	CMPK2, CYTOKINES, ECSIT, IBA1, IL6, INFLAMMATION
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TLR1 — AlphaFold Q9Y5S2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TLR1["TLR1"]
    Epilepsy{"Epilepsy"}
    TLR1 -->|"expressed in"| Epilepsy
    Ms{"Ms"}
    TLR1 -->|"expressed in"| Ms
    Als{"Als"}
    TLR1 -->|"activates"| Als
    TLR1 -->|"activates"| Ms
    HMGB1["HMGB1"]
    TLR1 -->|"expressed in"| HMGB1
    IKBKB["IKBKB"]
    TLR1 -->|"expressed in"| IKBKB
    IL8["IL8"]
    TLR1 -->|"expressed in"| IL8
    Nf__b(["Nf-Kappab"])
    TLR1 -->|"expressed in"| Nf__b
    Toll_Like_Receptor(["Toll-Like Receptor"])
    TLR1 -->|"interacts with"| Toll_Like_Receptor
    Immune_Response(["Immune Response"])
    TLR1 -->|"activates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    TLR1 -->|"implicated in"| neurodegeneration
    TLR4["TLR4"]
    TLR4 -->|"expressed in"| TLR1
    IL1B["IL1B"]
    IL1B -->|"expressed in"| TLR1
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"expressed in"| TLR1
    TLR3["TLR3"]
    TLR3 -->|"expressed in"| TLR1
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    PROINFLAMMATORY_CYTOKINES -->|"expressed in"| TLR1
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| TLR1
    RAGE["RAGE"]
    RAGE -->|"expressed in"| TLR1
    IRAK2["IRAK2"]
    IRAK2 -->|"expressed in"| TLR1
    IL10["IL10"]
    IL10 -->|"expressed in"| TLR1
    IRAK1["IRAK1"]
    IRAK1 -->|"expressed in"| TLR1
    IKBKG["IKBKG"]
    IKBKG -->|"expressed in"| TLR1
    TLR2["TLR2"]
    TLR2 -->|"expressed in"| TLR1
    style TLR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
Immune Response	activates	pathway	0.70
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Epilepsy	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
TLR2	activates	gene	0.60
TNF	activates	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
TLR4	activates	gene	0.60
MYD88	activates	gene	0.60
TLR7	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
TBK1	activates	gene	0.60
TLR9	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
CYTOKINES	activates	gene	0.60
IKBKB	expressed_in	gene	0.60
TREM2	activates	gene	0.60
IL8	expressed_in	gene	0.60
Toll-Like Receptor	interacts_with	pathway	0.60
HMGB1	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
TLR	activates	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
microglia	expressed_in	cell_type	0.55

Incoming (22)

Source	Relation	Type	Str
CMPK2	activates	gene	0.60
TLR4	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
TLR3	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
IRAK2	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
IRAK1	expressed_in	gene	0.60
IKBKG	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
TLR4	interacts_with	gene	0.60
TRAF6	activates	gene	0.60
ECSIT	activates	gene	0.60
TLR2	interacts_with	gene	0.60
TLR3	activates	gene	0.60
IL6	activates	gene	0.60
IBA1	activates	gene	0.60
NLRP3	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
TLR	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TLR1 in their description or question text

No additional research found