protein

FN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

362Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Aging, Als. Connected to 248 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FN1
Function	Fibronectin (FN1) is a high-molecular-weight extracellular matrix glycoprotein that plays crucial roles in cell adhesion, migration, and tissue morphogenesis.
Primary Expression	Hippocampus
Pathways	Akt, Pi3K, Angiogenesis, Epigenetic, Immune Response
GeneCards	FN1
Human Protein Atlas	FN1
Associated Diseases	Aging, Als, Carcinoma, Diabetes, Fibrosis
Interactions	ACTB, ACTG1, ADORA2B, AKT, Amyloid, AND
KG Connections	362 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FN1["FN1"]
    FN1 -.protects against.-> APOE4["APOE4"]
    FN1 -->|"component_of"| blood_brain_barrier["blood-brain barrier"]
    FN1 -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    FN1 -->|"causes"| gliosis["gliosis"]
    FN1 -->|"target for"| Glioblastoma["Glioblastoma"]
    FN1 -->|"target for"| Als["Als"]
    FN1 -->|"regulates"| Tumor["Tumor"]
    FN1 -->|"target for"| Ms["Ms"]
    APOE4 -->|"contributes to"| FN1
    ANXA2["ANXA2"] -->|"regulates"| FN1
    PI3K["PI3K"] -->|"target for"| FN1
    AKT["AKT"] -->|"activates"| FN1
    AGING["AGING"] -.protects against.-> FN1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.protects against.-> FN1
    CEBPD["CEBPD"] -->|"activates"| FN1
    EGFR["EGFR"] -->|"activates"| FN1
    GBM["GBM"] -->|"regulates"| FN1

Outgoing (238)

Target	Relation	Type	Str
APOE4	protects_against	gene	0.90
blood-brain barrier	component_of	phenotype	0.90
Als	activates	disease	0.85
Alzheimer's disease	protects_against	disease	0.80
gliosis	causes	phenotype	0.80
Glioblastoma Invasion	modulates	phenotype	0.80
Glioblastoma	activates	disease	0.75
Als	inhibits	disease	0.75
blood-brain barrier integrity	associated_with	process	0.75
GLIOBLASTOMA	activates	gene	0.70
Angiogenesis	activates	pathway	0.70
GBM	regulates	gene	0.70
GENES	activates	gene	0.70
Prostate Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Breast Cancer	inhibits	disease	0.65
Alzheimer	protects_against	disease	0.65
Aging	associated_with	disease	0.65
Aging	protects_against	disease	0.65
Als	protects_against	disease	0.65
Dementia	protects_against	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	expressed_in	disease	0.65
Retinopathy	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Senescence	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Tumor	inhibits	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ALS	causes	disease	0.65
Ms	regulates	disease	0.65
Diabetes	causes	disease	0.65
ALS	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Hypertension	causes	disease	0.65
Hypertension	activates	disease	0.65
Ms	interacts_with	disease	0.65
Ischemia	contributes_to	disease	0.65
Diabetes	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	associated_with	disease	0.65
Traumatic Brain Injury	activates	disease	0.65

Incoming (124)

Source	Relation	Type	Str
APOE4	contributes_to	gene	0.80
COMPLEMENT	contributes_to	gene	0.60
ALS	biomarker_for	gene	0.60
EGFR	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
AGING	protects_against	gene	0.60
FN1B	associated_with	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
ADORA2B	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
IL5	inhibits	gene	0.60
MCC	expressed_in	gene	0.60
COL1A1	associated_with	gene	0.60
PI3K	regulates	gene	0.60
KIF11	associated_with	gene	0.60
PHIP	regulates	gene	0.60
AND	regulates	gene	0.60
GLUT3	regulates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
APOE	interacts_with	gene	0.60
APOE3	interacts_with	gene	0.60
ATP8B1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
AKT	activates	gene	0.60
GRB2	interacts_with	gene	0.60
CEBPD	activates	gene	0.60
PI3K	activates	gene	0.60
EGFR	activates	gene	0.60
GBM	regulates	gene	0.60
FYN	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
VCP	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
CD44	activates	gene	0.60
GFAP	activates	gene	0.60
LGALS3	associated_with	gene	0.60
PECAM1	protects_against	gene	0.60
FOS	protects_against	gene	0.60
FGF1	protects_against	gene	0.60
FGF5	protects_against	gene	0.60
IL1A	associated_with	gene	0.60
XBP1	protects_against	gene	0.60
DNAJB9	protects_against	gene	0.60
LRP1	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
TIMP1	associated_with	gene	0.60
EXOSOMES	contributes_to	gene	0.60
POSTN	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FN1 in their description or question text

No additional research found

FN1

Understanding Entity Pages

Summary

Wiki Pages (9)

LRFN1 — Leucine Rich Repeat and Fibronectin Type III Domain Containing 1

PFN1 — Profilin 1

Mitofusin (MFN1/2) Neurons

PFN1 Gene

Mitofusin 1 (MFN1)

PFN1 Protein

MFN1 Protein

FN1 Protein (Fibronectin)