Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CEBPD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CEBPD is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, biomarker for. Associated with Als, Glioblastoma, Ms. Connected to 16 entities in the SciDEX knowledge graph.
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| Gene Symbol | CEBPD |
| Protein Type | Transcription Factor |
| Function | They function as homo- or heterodimers and regulate gene expression through their leucine zipper DNA-binding domains. |
| Primary Expression | various tissues including brain, where it plays important roles in: |
| Pathways | Invasion, Mtor |
| UniProt ID | Q99731 |
| Ensembl ID | ENSG00000172244 |
| GeneCards | CEBPD |
| Human Protein Atlas | CEBPD |
| Glial Cell Function | Regulation of astrocyte and microglial activation |
| Inflammatory Response | Control of pro-inflammatory cytokine expression |
| Metabolic Regulation | Modulation of glucose and lipid metabolism |
| Cell Differentiation | Involvement in cellular differentiation programs |
| Associated Diseases | neurodegeneration |
| Interactions | AND, EGFR, FN1, GENES, PI3K |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CEBPD["CEBPD"]
Ms{"Ms"}
CEBPD -->|"biomarker for"| Ms
Als{"Als"}
CEBPD -->|"activates"| Als
CEBPD -->|"activates"| Ms
Glioblastoma{"Glioblastoma"}
CEBPD -->|"regulates"| Glioblastoma
CTSD["CTSD"]
CEBPD -->|"biomarker for"| CTSD
CYP27A1["CYP27A1"]
CEBPD -->|"biomarker for"| CYP27A1
PI3K["PI3K"]
CEBPD -->|"activates"| PI3K
EGFR["EGFR"]
CEBPD -->|"activates"| EGFR
GBM["GBM"]
CEBPD -->|"regulates"| GBM
FN1["FN1"]
CEBPD -->|"activates"| FN1
Pi3K(["Pi3K"])
CEBPD -->|"activates"| Pi3K
neurodegeneration["neurodegeneration"]
CEBPD -->|"implicated in"| neurodegeneration
CD4["CD4"]
CD4 -->|"biomarker for"| CEBPD
style CEBPD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ovarian Aging | contributes_to | process | 0.90 |
| Aged Ovary | upregulates | phenotype | 0.85 |
| Transcription Factor Activity | mediates | mechanism | 0.80 |
| Ms | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Glioblastoma | regulates | disease | 0.65 |
| FN1 | activates | gene | 0.60 |
| Pi3K | activates | pathway | 0.60 |
| MTOR | regulates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| GLIOBLASTOMA | regulates | gene | 0.60 |
| CTSD | biomarker_for | gene | 0.60 |
| CYP27A1 | biomarker_for | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| GBM | regulates | gene | 0.60 |
| Invasion | regulates | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| AGING | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CEBPD in their description or question text
No additional research found