concept

ZFP36

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZFP36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ZFP36 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Atherosclerosis. Connected to 119 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ZFP36
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANXA2, APOPTOSIS, ASTROCYTES
Related Diseases	Als, Alzheimer, Atherosclerosis
Related Pathways	Apoptosis, apoptosis pathway, autophagy

Wiki Pages (1)

Knowledge base pages for this entity

ZFP36L2 — Zinc Finger Protein L2

gene · 2609 words

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Pathway Diagram

graph TD
    ZFP36["ZFP36"]
    ZFP36 -.protects against.-> ferroptosis["ferroptosis"]
    ZFP36 -->|"inhibits"| ATG16L1["ATG16L1"]
    ZFP36 -->|"inhibits"| autophagy["autophagy"]
    ZFP36 -->|"interacts"| Ms["Ms"]
    ZFP36 -->|"expressed in"| Tumor["Tumor"]
    ZFP36 -->|"regulates"| Leukemia["Leukemia"]
    ZFP36 -->|"activates"| Inflammation["Inflammation"]
    ZFP36 -->|"activates"| Stroke["Stroke"]
    ZFP36 -->|"activates"| Als["Als"]
    FBXW7["FBXW7"] -->|"inhibits"| ZFP36
    DMSO["DMSO"] -->|"expressed in"| ZFP36
    TNF["TNF"] -->|"expressed in"| ZFP36
    BCL2["BCL2"] -->|"regulates"| ZFP36
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ZFP36
    ANXA2["ANXA2"] -->|"activates"| ZFP36
    ICAM1["ICAM1"] -->|"activates"| ZFP36
    CD44["CD44"] -->|"activates"| ZFP36
    HMOX1["HMOX1"] -->|"activates"| ZFP36
    SPP1["SPP1"] -->|"activates"| ZFP36

Outgoing (81)

Target	Relation	Type	Str
TXNIP	binds	gene	0.95
Hypoxic-Ischemic Brain Damage	protects_against	disease	0.95
Nlrp3 Inflammasome	inhibits	pathway	0.95
TXNIP	downregulates	gene	0.95
ferroptosis	protects_against	pathway	0.90
Neuronal Apoptosis	inhibits	process	0.90
ATG16L1	inhibits	gene	0.90
autophagy	inhibits	pathway	0.90
Pyroptosis	inhibits	process	0.90
Hippocampal Neurons	expressed_in	cell_type	0.85
Leukemia	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Lymphoma	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	inhibits	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Necroptosis	associated_with	pathway	0.60
CH25H	activates	gene	0.60
ATF3	activates	gene	0.60
VIM	activates	gene	0.60
AND	expressed_in	gene	0.60
CCL2	expressed_in	gene	0.60
FTH1	associated_with	gene	0.60
ZFP36L2	associated_with	gene	0.60
HSPB1	activates	gene	0.60
IL-6	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
HSPB1	therapeutic_target	gene	0.60
SERPINA3	expressed_in	gene	0.60
PCK1	therapeutic_target	gene	0.60
CD163	expressed_in	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
P53	associated_with	gene	0.60

Incoming (71)

Source	Relation	Type	Str
Txnip/Nlrp3 Inflammasome Pathway	therapeutic_target	pathway	0.90
FBXW7	inhibits	gene	0.90
RNA	interacts_with	gene	0.70
NLRP3	activates	gene	0.60
TXNIP	activates	gene	0.60
NLRP3	inhibits	gene	0.60
FERROPTOSIS	regulates	gene	0.60
FTH1	associated_with	gene	0.60
AND	associated_with	gene	0.60
FBXW7	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DMSO	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ZFP36L2	associated_with	gene	0.60
C5AR1	expressed_in	gene	0.60
TNF	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
TP53	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
BECN1	associated_with	gene	0.60
COL1A1	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
ROS	associated_with	gene	0.60
P53	associated_with	gene	0.60
PCK1	therapeutic_target	gene	0.60
SERPINA3	expressed_in	gene	0.60
GENES	therapeutic_target	gene	0.60
HSPB1	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
TXNIP	inhibits	gene	0.60
AND	inhibits	gene	0.60
TCR	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
CXCR4	inhibits	gene	0.60
SQSTM1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
FN1	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
BCL2	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
PYCARD	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ZFP36 in their description or question text

No additional research found