gene

KIF11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

Kinesin family member 11 - mitotic spindle motor protein

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KIF11
Full Name	Kinesin Family Member 11
Chromosome	10p11.21
Protein Type	Kinesin Motor Protein
Function	KIF11 (Eg5) is a plus-end-directed kinesin motor protein with critical functions:
UniProt ID	P52733
NCBI Gene ID	3832
Ensembl ID	ENSG00000138160
OMIM	158745
GeneCards	KIF11
Human Protein Atlas	KIF11
Spindle formation	Generates outward force to push spindle poles apart
Bipolarity establishment	Essential for converting monopolar to bipolar spindles
Spindle maintenance	Stabilizes bipolar spindle during metaphase
Metaphase alignment	Maintains chromosome alignment at the metaphase plate
Associated Diseases	neurodegeneration
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KIF11 — AlphaFold P52733 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KIF11 Gene

gene · 1166 words

→

Pathway Diagram

graph TD
    KIF11["KIF11"]
    Cancer{"Cancer"}
    KIF11 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    KIF11 -->|"expressed in"| Tumor
    Fibrosis{"Fibrosis"}
    KIF11 -->|"expressed in"| Fibrosis
    Ms{"Ms"}
    KIF11 -->|"expressed in"| Ms
    COL1A1["COL1A1"]
    KIF11 -->|"associated with"| COL1A1
    DNM1L["DNM1L"]
    KIF11 -->|"associated with"| DNM1L
    POSTN["POSTN"]
    KIF11 -->|"associated with"| POSTN
    FN1["FN1"]
    KIF11 -->|"associated with"| FN1
    RAGE["RAGE"]
    KIF11 -->|"expressed in"| RAGE
    Tgf__(["Tgf-Beta"])
    KIF11 -->|"expressed in"| Tgf__
    neurodegeneration["neurodegeneration"]
    KIF11 -->|"implicated in"| neurodegeneration
    PSMA3["PSMA3"]
    PSMA3 -->|"associated with"| KIF11
    CANCER["CANCER"]
    CANCER -->|"expressed in"| KIF11
    KIF23["KIF23"]
    KIF23 -->|"associated with"| KIF11
    MCC["MCC"]
    MCC -->|"expressed in"| KIF11
    COL1A1 -->|"associated with"| KIF11
    style KIF11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Fibrosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
POSTN	associated_with	gene	0.60
FN1	associated_with	gene	0.60
Tgf-Β	expressed_in	pathway	0.60
COL1A1	associated_with	gene	0.60
RAGE	expressed_in	gene	0.60
DNM1L	associated_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
CANCER	expressed_in	gene	0.60
COL1A1	associated_with	gene	0.60
MCC	expressed_in	gene	0.60
PSMA3	associated_with	gene	0.60
KIF23	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KIF11 in their description or question text

No additional research found