gene 1,437 words KG: PFN1
Contents

PFN1 — Profilin 1

🧬 Gene Info
Gene SymbolPFN1
Full NameProfilin 1
Chromosome17p13.3
Protein FamilyProfilin family
Functionregulating cytoskeletal dynamics
Molecular Weight15 kDa
Amino Acids140 aa
Exons4
PathwaysChaperone
UniProt ID[P07737](https://www.uniprot.org/uniprot/P07737)
Ensembl IDENSG00000108518
OMIM176610
GeneCardsPFN1
Human Protein AtlasPFN1
Actin-binding siteInteracts with G-actin (monomeric actin)
Associated DiseasesAls, disease, neurodegeneration
InteractionsALS, DNAJB6
SciDEX HypothesesProfilin-1 Cytoskeletal Checkpoint Enhancement
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (6)

HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.85
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69

Related Analyses (3)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (7)

spinal-cord
brain_region · KG edge: expressed_in
Motor Neuron Disease
redirect · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
DNAJB6 Gene
gene · KG edge: activates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DNAJB6 activates PFN1
GAIN associated_with PFN1
PFN1 associated_with GAIN
PFN1 activates DNAJB6
PFN1 implicated_in protein misfolding
DNAJB6 co_expressed_with PFN1
PFN1 associated_with neurodegeneration
CXCL10 co_associated_with PFN1
PFN1 associated_with ALS
PFN1 associated_with Als

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