gene 2,282 words KG: LRFN1
Contents

LRFN1 — Leucine Rich Repeat and Fibronectin Type III Domain Containing 1

🧬 Gene Info
Gene SymbolLRFN1
Full NameLeucine Rich Repeat and Fibronectin Type III Domain Containing 1
AliasesSALM1
Chromosome19q13.32
Functionis a neuronal synaptic adhesion molecule that plays critical roles in synapse formation, maintenance, and plasticity.
Primary Expressionthe central nervous system:
Subcellular LocalizationWithin neurons, LRFN1 localizes to:
Molecular Weight75 kDa
UniProt IDQ9ULJ8
NCBI Gene ID57608
Ensembl IDENSG00000171530
OMIM610099
GeneCardsLRFN1
Human Protein AtlasLRFN1
Associated DiseasesALS, Alzheimer, dementia, frontotemporal, neurodegeneration
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 3 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (12 edges)

COMT co_expressed_with LRFN1
LRFN1 co_expressed_with MAPT
LRFN1 co_expressed_with RAB3B
LRFN1 associated_with neurodegeneration
LRFN1 associated_with frontotemporal
CADM1 implicated_in LRFN1
COMT implicated_in LRFN1
ITPKA implicated_in LRFN1
LRFN1 implicated_in NCAN
LRFN1 implicated_in RAB3B

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