concept

POSTN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POSTN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

1Hypotheses

0Analyses

41Outgoing

25Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	POSTN
Key Genes/Proteins	Actin, AND, ANG, AUTOPHAGY, CLOCK, COL1A1
Related Diseases	Cardiac, Fibrosis, FIBROSIS
Related Pathways	Angiogenesis, Autophagy, autophagy pathway

Pathway Diagram

graph TD
    POSTN["POSTN"]
    POSTN -->|"encodes"| PERIOSTIN["PERIOSTIN"]
    POSTN -->|"inhibits"| Fibrosis["Fibrosis"]
    POSTN -->|"activates"| Ms["Ms"]
    POSTN -->|"activates"| Tumor["Tumor"]
    POSTN -->|"activates"| Glioblastoma["Glioblastoma"]
    POSTN -->|"activates"| Cardiac["Cardiac"]
    TAZ["TAZ"] -->|"activates"| POSTN
    YAP["YAP"] -->|"activates"| POSTN
    PIEZO1["PIEZO1"] -->|"inhibits"| POSTN
    ANG["ANG"] -->|"activates"| POSTN
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| POSTN
    EXOSOMES["EXOSOMES"] -->|"contributes to"| POSTN
    MCC["MCC"] -->|"expressed in"| POSTN
    AND["AND"] -->|"inhibits"| POSTN

Outgoing (41)

Target	Relation	Type	Str
PERIOSTIN	encodes	protein	0.80
Fibrosis	inhibits	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	activates	disease	0.65
Fibrosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Pulmonary Fibrosis	activates	disease	0.65
Ms	contributes_to	disease	0.65
Fibrosis	activates	disease	0.65
Cardiac	activates	disease	0.65
PIEZO1	inhibits	gene	0.60
PIEZO2	activates	gene	0.60
Autophagy	activates	pathway	0.60
TAZ	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
YAP	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Fibroblast	inhibits	cell_type	0.60
Angiogenesis	activates	pathway	0.60
RAGE	expressed_in	gene	0.60
TBK1	activates	gene	0.60
GBM	inhibits	gene	0.60
Yap/Taz	activates	pathway	0.60
CLOCK	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ANG	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
YTHDF1	activates	gene	0.60
PIEZO	activates	gene	0.60
PIEZO1	activates	gene	0.60
Actin	activates	protein	0.60
SLC32A1	targets	gene	0.60
autophagy pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
FN1	associated_with	gene	0.60
Angiogenesis	contributes_to	pathway	0.60
Fibroblast	activates	cell_type	0.60
AND	inhibits	gene	0.60
Fibroblast	expressed_in	cell_type	0.55

Incoming (25)

Source	Relation	Type	Str
KIF11	associated_with	gene	0.60
YTHDF1	activates	gene	0.60
RNA	activates	gene	0.60
PIEZO2	activates	gene	0.60
COL1A1	associated_with	gene	0.60
PIEZO	activates	gene	0.60
GLUL	targets	gene	0.60
MAPK10	targets	gene	0.60
MAPT	targets	gene	0.60
TAZ	activates	gene	0.60
YAP	activates	gene	0.60
PIEZO1	inhibits	gene	0.60
ANG	activates	gene	0.60
PIEZO1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
LRP1	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
TIMP1	associated_with	gene	0.60
EXOSOMES	contributes_to	gene	0.60
MCC	expressed_in	gene	0.60
AND	inhibits	gene	0.60
FIBROSIS	activates	disease	0.50
Cardiac	activates	disease	0.50
FIBROSIS	decreases_risk	disease	0.50
ZO1	associated_with	gene	0.35

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Early Postnatal TGF-beta Signaling Establishes Lifelong Regi	0.500	neuroinflammation	How do regional, age, and sex-dependent

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning POSTN in their description or question text

No additional research found