concept

EXOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1231Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

EXOSOMES is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 578 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	EXOSOMES
Key Genes/Proteins	Actin, ADAM10, ADAR1, AGING, AGO2, AKT
Related Diseases	Aging, Als
Related Pathways	Adaptive Immunity, Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Exosomes

entity · 1639 words

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Pathway Diagram

flowchart TD
    EXOSOMES(["EXOSOMES"])
    Inflammation["Inflammation"]
    Blood_Brain_Barrier["Blood-Brain Barrier"]
    Als["Als"]
    Neuroinflammation["Neuroinflammation"]
    Tumor["Tumor"]
    Cancer["Cancer"]
    Aging["Aging"]
    INFLAMMATION(["INFLAMMATION"])
    MIRNAS(["MIRNAS"])
    CANCER(["CANCER"])
    Apoptosis["Apoptosis"]
    APOPTOSIS(["APOPTOSIS"])

    EXOSOMES -->|"activates"| Inflammation
    EXOSOMES -->|"therapeutic target"| Inflammation
    EXOSOMES -->|"therapeutic target"| Blood_Brain_Barrier
    EXOSOMES -->|"therapeutic target"| Als
    EXOSOMES -->|"therapeutic target"| Neuroinflammation
    EXOSOMES -->|"therapeutic target"| Tumor
    EXOSOMES -->|"therapeutic target"| Cancer
    EXOSOMES -->|"therapeutic target"| Aging
    EXOSOMES -->|"biomarker for"| Als
    INFLAMMATION -->|"therapeutic target"| EXOSOMES
    MIRNAS -->|"therapeutic target"| EXOSOMES
    INFLAMMATION -->|"activates"| EXOSOMES
    CANCER -->|"therapeutic target"| EXOSOMES
    EXOSOMES -->|"therapeutic target"| Apoptosis
    APOPTOSIS -->|"therapeutic target"| EXOSOMES

    style EXOSOMES fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (799)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Aging	therapeutic_target	disease	1.00
Als	biomarker_for	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Aging	activates	disease	0.95
Ischemia	activates	disease	0.95
Parkinson	therapeutic_target	disease	0.95
Alzheimer	therapeutic_target	disease	0.95
miR-3960	component_of	biomarker	0.92
Pre-Regenerative Niche	involved_in	structure	0.90
Blood-brain barrier	associated_with	entity	0.90
Oxidative Stress	therapeutic_target	pathway	0.90
Microrna	therapeutic_target	pathway	0.90
Stem Cell	therapeutic_target	pathway	0.90
Fibrosis	activates	disease	0.85
Als	regulates	disease	0.85
Drug Resistance	suppresses	phenotype	0.85
Stroke	therapeutic_target	disease	0.85
MMP	inhibits	protein	0.85
Diabetes	regulates	disease	0.85
Als	activates	disease	0.85
Cancer	biomarker_for	disease	0.85
Drug Uptake	promotes	process	0.85
extracellular signaling	regulates	process	0.85
Als	inhibits	disease	0.85
Ischemic stroke	treats	disease	0.80
Drug Resistance	contributes_to	phenotype	0.80
miR-522	mediates	biomarker	0.80
Apoptosis	inhibits	pathway	0.80
Exocytosis	activates	pathway	0.80
Stem Cell	activates	pathway	0.80
Drug Resistance	therapeutic_target	pathway	0.80
Mitophagy	activates	pathway	0.80
Differentiation	activates	pathway	0.80
CANCER	associated_with	gene	0.80
Nf-Κb	activates	pathway	0.80
Alzheimer	biomarker_for	disease	0.75
Inflammation	associated_with	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Cardiovascular	activates	disease	0.75
Cancer	activates	disease	0.75
Multiple Sclerosis	therapeutic_target	disease	0.75
Ischemia	therapeutic_target	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75

Incoming (432)

Source	Relation	Type	Str
MIRNAS	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
INFLAMMATION	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
Ps1292-Lrrk2	expressed_in	biomarker	0.95
Endothelial Cells	product_of	cell_type	0.95
Adipose-Derived Mesenchymal Stem Cells	associated_with	cell_type	0.95
NEUROINFLAMMATION	therapeutic_target	gene	0.90
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.90
OXIDATIVE STRESS	therapeutic_target	gene	0.90
Caf	expressed_in	cell_type	0.85
Fibroblasts	product_of	cell_type	0.85
TGF-β	associated_with	entity	0.80
c(RGDyK)	binds	entity	0.80
EGFR	regulates	gene	0.80
MIRNAS	activates	gene	0.80
AGING	therapeutic_target	gene	0.80
PARKINSON'S DISEASE	therapeutic_target	gene	0.80
DNA	therapeutic_target	gene	0.80
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.80
AKT	activates	gene	0.80
CANCER	biomarker_for	gene	0.80
MIRNAS	associated_with	gene	0.80
APOPTOSIS	inhibits	gene	0.80
MITOPHAGY	activates	gene	0.80
NF-ΚB	activates	gene	0.80
PARKIN	activates	gene	0.80
STROKE	therapeutic_target	gene	0.80
MICRORNAS	therapeutic_target	gene	0.80
AMPK	activates	gene	0.70
MITOCHONDRIA	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	0.70
ALS	biomarker_for	gene	0.70
MICRORNAS	regulates	gene	0.70
PINK1	activates	gene	0.70
cellular nanoporation	activates	process	0.70
OPTN	activates	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
JUN	activates	gene	0.70
EPILEPSY	therapeutic_target	gene	0.70
PARKINSON	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
OVERVIEW	therapeutic_target	gene	0.70
CANCER	activates	gene	0.70
AKT	therapeutic_target	gene	0.70
MICRORNAS	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene Co-expression Network Analysis of AD Progression Modules

neurodegeneration | 2026-04-16 | 0 hypotheses

Investigate prion-like spreading of tau pathology through connected brain region

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.640

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

EXOSOMES

Understanding Entity Pages

Summary

Wiki Pages (1)

Exosomes

Pathway Diagram

Outgoing (799)

Incoming (432)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Gene Co-expression Network Analysis of AD Progression Modules

Investigate prion-like spreading of tau pathology through connected brain region

Experiments (0)

Related Papers (0)

Debates (3)

Investigate prion-like spreading of tau pathology through connected brain region

What co-expression modules are shared and unique across brain regions in AD, and

Is TYROBP a genuine therapeutic target in AD, or is it a downstream marker of mi