gene

CCS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

1Analyses

37Outgoing

15Incoming

0Experiments

1Debates

Summary

Copper Chaperone for Superoxide Dismutase - essential for SOD1 maturation and copper delivery in neurons

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🧬 Gene Info

Gene Symbol	CCS
Full Name	Copper Chaperone for Superoxide Dismutase
Chromosome	11q13.2
Function	CCS performs essential functions in copper homeostasis and SOD1 maturation
Amino Acids	274 aa
Pathways	Chaperone
UniProt ID	O15136
NCBI Gene ID	9973
Ensembl ID	ENSG00000129521
OMIM	603646
GeneCards	CCS
Human Protein Atlas	CCS
Associated Diseases	Cardiovascular, Inflammation, Ischemia, Stroke
Interactions	AND, CANCER, FN1, GAIN, GENES, JAK
KG Connections	52 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CCS — AlphaFold O15136 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CCS Gene

gene · 608 words

→

CCS Protein

protein · 698 words

→

Pathway Diagram

graph TD
    CCS["CCS"]
    Ischemia{"Ischemia"}
    CCS -->|"associated with"| Ischemia
    Stroke{"Stroke"}
    CCS -->|"associated with"| Stroke
    Cardiovascular{"Cardiovascular"}
    CCS -->|"associated with"| Cardiovascular
    Inflammation{"Inflammation"}
    CCS -->|"associated with"| Inflammation
    INFLAMMATION["INFLAMMATION"]
    CCS -->|"associated with"| INFLAMMATION
    APOB["APOB"]
    CCS -->|"associated with"| APOB
    neurodegeneration["neurodegeneration"]
    CCS -->|"implicated in"| neurodegeneration
    IL_6["IL-6"]
    IL_6 -->|"associated with"| CCS
    style CCS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Als	inhibits	disease	0.75
Tumor	inhibits	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Breast Cancer	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
CACNA1F	contributes_to	gene	0.60
CACNA1I	contributes_to	gene	0.60
CACNA2D1	contributes_to	gene	0.60
CACNA1E	contributes_to	gene	0.60
CACNA1H	contributes_to	gene	0.60
CACNA1D	contributes_to	gene	0.60
CACNA1G	contributes_to	gene	0.60
CACNA1A	contributes_to	gene	0.60
INFLAMMATION	associated_with	gene	0.60
FN1	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
JAK	inhibits	gene	0.60
Metastasis	inhibits	pathway	0.60
Chaperone	activates	pathway	0.60
Invasion	inhibits	pathway	0.60
APOB	associated_with	gene	0.60
Jak-Stat	inhibits	pathway	0.60
STAT3	inhibits	gene	0.60
JARID2	inhibits	gene	0.60
UBIQUITIN	activates	gene	0.60
VIM	inhibits	gene	0.60
SOD1	interacts_with	gene	0.60
CACNA1C	contributes_to	gene	0.60
CACNA2D2	contributes_to	gene	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Glycolysis	inhibits	pathway	0.60
AND	interacts_with	gene	0.60
Chaperone	interacts_with	pathway	0.60

Incoming (15)

Source	Relation	Type	Str
CACNA1G	contributes_to	gene	0.60
CACNA1E	contributes_to	gene	0.60
CACNA2D1	contributes_to	gene	0.60
GAIN	activates	gene	0.60
CACNA1F	contributes_to	gene	0.60
CACNA1H	contributes_to	gene	0.60
CACNA1D	contributes_to	gene	0.60
CACNA1A	contributes_to	gene	0.60
CACNA1C	contributes_to	gene	0.60
CACNA1I	contributes_to	gene	0.60
MIRNAS	biomarker_for	gene	0.60
ATP	associated_with	gene	0.60
GENES	activates	gene	0.60
AND	contributes_to	gene	0.60
IL-6	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study demonstrates that exercise-conditioned plasma transfers cognitive bene

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning CCS in their description or question text

No additional research found