concept

UBIQUITIN-PROTEASOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBIQUITIN-PROTEASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1399Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

UBIQUITIN-PROTEASOME is a concept in neurodegeneration research. Key relationships include: co discussed, activates, stabilizes. Associated with FRONTOTEMPORAL. Connected to 16 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	UBIQUITIN-PROTEASOME
Key Genes/Proteins	ACTIN, ATG, CHMP2B, DNA, GSH
Related Diseases	ALS, CANCER, FRONTOTEMPORAL DEMENTIA, FTD, LATE

Pathway Diagram

graph TD
    UBIQUITIN_PROTEASOME["UBIQUITIN-PROTEASOME"]
    UBIQUITIN_PROTEASOME -->|"interacts"| Unfolded_Protein_Response["Unfolded Protein Response"]
    UBIQUITIN_PROTEASOME -->|"interacts"| Mtor["Mtor"]
    OCLN["OCLN"] -->|"activates"| UBIQUITIN_PROTEASOME
    BECN1["BECN1"] -->|"activates"| UBIQUITIN_PROTEASOME
    CLDN5["CLDN5"] -->|"activates"| UBIQUITIN_PROTEASOME
    CAV1["CAV1"] -->|"activates"| UBIQUITIN_PROTEASOME
    HIF1A["HIF1A"] -->|"activates"| UBIQUITIN_PROTEASOME
    ACTB["ACTB"] -->|"regulates"| UBIQUITIN_PROTEASOME
    CDC42["CDC42"] -->|"regulates"| UBIQUITIN_PROTEASOME
    CASP3["CASP3"] -->|"regulates"| UBIQUITIN_PROTEASOME
    SQSTM1["SQSTM1"] -->|"regulates"| UBIQUITIN_PROTEASOME
    TUBB3["TUBB3"] -->|"regulates"| UBIQUITIN_PROTEASOME

Outgoing (50)

Target	Relation	Type	Str
protein misfolding	mediates	process	0.80
neural stem cells	active_in	cell_type	0.80
neurons	active_in	cell_type	0.70
unfolded protein response	crosstalk_with	pathway	0.70
necroptosis	mediates	process	0.60
pyroptosis	mediates	process	0.60
ferroptosis	mediates	process	0.60
blood-brain barrier	active_in	brain_region	0.60
endothelial cells	active_in	cell_type	0.60
cerebellum	active_in	brain_region	0.60
Unfolded Protein Response	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
disease	associated_with	disease	0.50
FBXW7	regulates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	regulates	concept	0.50
FBXW7	activates	concept	0.50
Endothelial	activates	cell_type	0.50
ALZHEIMER'S	associated_with	concept	0.50
Proteostasis	associated_with	process	0.50
Chaperone	regulates	pathway	0.50
Protein Folding	regulates	pathway	0.50
Proteins	protects_against	protein	0.50
FRONTOTEMPORAL	activates	concept	0.50
Neuron	stabilizes	cell_type	0.50
T Cell	associated_with	cell_type	0.50
RAPAMYCIN	activates	concept	0.50
IPSC	activates	concept	0.50
Reactive Oxygen Species	activates	process	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
Proteins	interacts_with	protein	0.50
ENDOPLASMIC RETICULUM	interacts_with	concept	0.50
Stem Cell	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Cerebrovascular	activates	pathway	0.50
Endothelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
TJP1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
Proteins	activates	protein	0.50
T Cell	activates	cell_type	0.50
Microglia	activates	cell_type	0.50
Stem Cell	regulates	cell_type	0.50
Neuron	degrades	cell_type	0.50
T Cell	causes	cell_type	0.50
Dopaminergic	activates	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
VALOSIN	co_discussed	gene	0.40

Incoming (1349)

Source	Relation	Type	Str
UBIQUITIN	associated_with	gene	1.00
Als	therapeutic_target	disease	1.00
UBIQUITIN	regulates	gene	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
UBIQUITIN	therapeutic_target	gene	1.00
Als	activates	disease	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
UBIQUITIN	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Parkinson	therapeutic_target	disease	1.00
AUTOPHAGY	regulates	gene	1.00
AUTOPHAGY	activates	gene	1.00
PARKINSON'S DISEASE	therapeutic_target	gene	1.00
APP	participates_in	gene	0.90
MYC	participates_in	gene	0.90
PRKN	participates_in	gene	0.90
CALCOCO2	participates_in	gene	0.90
NBR1	participates_in	gene	0.90
NLRP3	participates_in	gene	0.90
MAP1LC3B	participates_in	gene	0.90
RNA	participates_in	gene	0.90
OPTN	participates_in	gene	0.90
NDP52	participates_in	gene	0.90
SQSTM1	participates_in	gene	0.90
TNF	participates_in	gene	0.90
PS1	participates_in	gene	0.90
MAPK	participates_in	gene	0.90
NEURODEGENERATION	activates	gene	0.90
NEURODEGENERATION	associated_with	gene	0.90
PARKINSON	therapeutic_target	gene	0.90
Neurodegeneration	associated_with	disease	0.90
UBIQUITIN	inhibits	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
Neurodegeneration	activates	disease	0.90
TDP-43	participates_in	gene	0.85
DAM microglia	expressed_in	cell_type	0.85
GAPDH	participates_in	gene	0.80
RB1CC1	participates_in	gene	0.80
STX17	participates_in	gene	0.80
CREB	participates_in	gene	0.80
SNAP29	participates_in	gene	0.80
GABARAP	participates_in	gene	0.80
CRBN	participates_in	gene	0.80
VAMP8	participates_in	gene	0.80
UCHL1	participates_in	gene	0.80
CD38	participates_in	gene	0.80
SIRT1	participates_in	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBIQUITIN-PROTEASOME in their description or question text

No additional research found