gene

VALOSIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VALOSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

214Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

VALOSIN is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 130 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VCP
Aliases	Valosin-Containing Protein
Chromosome	9p13.3
Function	of 806 amino acids with a molecular weight of approximately 97 kDa[@kobayashi2000]
Molecular Weight	97 kDa
Amino Acids	806 aa
Exons	17
Pathways	Er Stress
GeneCards	VCP
Human Protein Atlas	VCP
N-terminal domain (1-200 aa)	Contains the N/D1 linker and mediates cofactor binding. The N-domain itself adopts a double-psi beta barrel fold that interacts with various cofactors including UFD1-NPL4, p47, and UBXD proteins.
D1 ATPase domain (200-400 aa)	The first ATPase domain responsible for hexamer assembly. This domain forms the core of the ring structure and contributes to ATP-dependent conformational changes.
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Ms
Interactions	Actin, ALS, ALS-CAUSING MUTATIONS, AMYOTROPHIC LATERAL SCLEROSIS, AND, App
KG Connections	214 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VCP (Valosin-Containing Protein)

protein · 1654 words

→

Pathway Diagram

graph TD
    VALOSIN["VALOSIN"]
    VALOSIN -->|"regulates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    VALOSIN -->|"regulates"| Ms["Ms"]
    VALOSIN -->|"regulates"| Dementia["Dementia"]
    VALOSIN -->|"activates"| Neurodegeneration["Neurodegeneration"]
    VALOSIN -->|"activates"| Als["Als"]
    VALOSIN -->|"regulates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    JUN["JUN"] -->|"regulates"| VALOSIN
    SPHK1["SPHK1"] -->|"activates"| VALOSIN
    TARDBP["TARDBP"] -->|"activates"| VALOSIN
    PINK1["PINK1"] -->|"activates"| VALOSIN
    LC3["LC3"] -->|"activates"| VALOSIN
    MTOR["MTOR"] -->|"activates"| VALOSIN
    PTEN["PTEN"] -->|"activates"| VALOSIN
    VCP["VCP"] -->|"activates"| VALOSIN
    TBK1["TBK1"] -->|"activates"| VALOSIN
    CHMP2B["CHMP2B"] -->|"activates"| VALOSIN

Outgoing (123)

Target	Relation	Type	Str
Neuroinflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Ftd	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Dementia	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
DEMENTIA	associated_with	gene	0.60
MATR3	associated_with	gene	0.60
AND	inhibits	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
EXOSOMES	activates	gene	0.60
NEURON	activates	gene	0.60
RNA	regulates	gene	0.60
AND	regulates	gene	0.60
App	activates	protein	0.60
VCP	associated_with	gene	0.60
LC3	activates	gene	0.60
TBK1	activates	gene	0.60
NLRP3	expressed_in	gene	0.60
VCP	activates	gene	0.60
MTOR	activates	gene	0.60
OVERVIEW	activates	gene	0.60
CHMP2B	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
VCP	degrades	entity	0.60
Er Stress	regulates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Unfolded Protein Response	activates	pathway	0.60
Proteasome	activates	pathway	0.60
Mtor	activates	pathway	0.60
ALS	associated_with	gene	0.60

Incoming (91)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
FTD	activates	entity	0.60
G3BP1	degrades	entity	0.60
TDP-43	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
NEURON	activates	gene	0.60
DEMENTIA	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
NEURON	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
MATR3	associated_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ASTROCYTES	activates	gene	0.60
RNA	associated_with	gene	0.60
SPHK1	activates	gene	0.60
TARDBP	activates	gene	0.60
PINK1	activates	gene	0.60
HNRNPA1	associated_with	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
PTEN	activates	gene	0.60
VCP	activates	gene	0.60
TBK1	activates	gene	0.60
CHMP2B	activates	gene	0.60
OVERVIEW	activates	gene	0.60
TFEB	activates	gene	0.60
VCP	expressed_in	gene	0.60
UBIQUITIN	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
OPTINEURIN	associated_with	gene	0.60
BECN1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
G3BP1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
VCP	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
OPTINEURIN	activates	gene	0.60
MAP1LC3	activates	gene	0.60
ALS-CAUSING MUTATIONS	activates	gene	0.60
ATG	activates	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VALOSIN in their description or question text

No additional research found