concept

DOPAMINERGIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOPAMINERGIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1385Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

9Experiments

0Debates

Summary

DOPAMINERGIC is a concept in neurodegeneration research. Key relationships include: co discussed, causes, regulates. Associated with NEURODEGENERATION, PARKINSON, PARKINSON'S. Connected to 145 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DOPAMINERGIC
Key Genes/Proteins	ACHE, ACTB, AD, AIF1, AKT, Alpha-Synuclein
Related Diseases	aging, Alzheimer'S Disease

Pathway Diagram

graph TD
    DOPAMINERGIC["DOPAMINERGIC"]
    DOPAMINERGIC -->|"causes"| NEURON["NEURON"]
    DOPAMINERGIC -->|"causes"| NEURONS["NEURONS"]
    DOPAMINERGIC -->|"causes"| SENESCENCE["SENESCENCE"]
    DOPAMINERGIC -->|"causes"| PARKIN["PARKIN"]
    DOPAMINERGIC -->|"causes"| PARKINSON["PARKINSON"]
    DOPAMINERGIC -->|"causes"| PARKINSON_S["PARKINSON'S"]
    DOPAMINERGIC -->|"causes"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    DOPAMINERGIC -->|"causes"| SUBSTANTIA_NIGRA["SUBSTANTIA NIGRA"]
    DOPAMINERGIC -->|"regulates"| PI3K["PI3K"]
    AKT["AKT"] -->|"regulates"| DOPAMINERGIC
    ASTROCYTE["ASTROCYTE"] -->|"interacts"| DOPAMINERGIC
    ASTROCYTES["ASTROCYTES"] -->|"interacts"| DOPAMINERGIC
    COMPLEMENT["COMPLEMENT"] -->|"activates"| DOPAMINERGIC
    APOPTOSIS["APOPTOSIS"] -->|"causes"| DOPAMINERGIC
    AMPK["AMPK"] -->|"activates"| DOPAMINERGIC
    AUTOPHAGY["AUTOPHAGY"] -->|"promotes"| DOPAMINERGIC

Outgoing (496)

Target	Relation	Type	Str
NEURONS	biomarker_for	cell_type	0.70
DRD2	inhibits	gene	0.70
TFEB	activates	gene	0.70
MAPT	activates	gene	0.70
MICROGLIA	expresses	cell_type	0.70
VPS35	associated_with	gene	0.70
JAK	inhibits	gene	0.70
WNT	activates	gene	0.70
SNCA	activates	gene	0.70
PLA2G6	associated_with	gene	0.70
GBA	protects_against	gene	0.70
SNCA	markers	gene	0.70
TFEB	causes	gene	0.70
FBXO7	associated_with	gene	0.70
JAK	activates	gene	0.70
NECROPTOSIS	activates	pathway	0.70
MLKL	activates	gene	0.70
TNF	activates	gene	0.70
MICROGLIA	mediates	cell_type	0.70
SLC6A3	regulates	gene	0.70
PINK1	associated_with	gene	0.70
MICROGLIA	disrupts	cell_type	0.70
TREM2	disrupts	gene	0.70
RAGE	interacts_with	gene	0.70
LRRK2	associated_with	gene	0.70
GABAERGIC	activates	cell_type	0.70
TFEB	associated_with	gene	0.70
SYNJ1	associated_with	gene	0.70
PARK7	associated_with	gene	0.70
DRD2	regulates	gene	0.70
WNT	causes	gene	0.70
NEURONS	enhances	cell_type	0.70
GBA	expresses	gene	0.70
PLP1	activates	gene	0.70
NEURONS	disrupts	cell_type	0.70
PINK1	activates	gene	0.70
MOTOR NEURON	expressed_in	cell_type	0.70
NOTCH	transports	gene	0.70
HTR2A	regulates	gene	0.70
PINK1	interacts_with	gene	0.70
DRD2	activates	gene	0.70
GLUTAMATERGIC	inhibits	cell_type	0.70
SLC6A4	regulates	gene	0.70
NECROPTOSIS	protects_against	pathway	0.70
GLUTAMATERGIC	activates	cell_type	0.70
STING	associated_with	gene	0.70
MICROGLIA	causes	cell_type	0.70
LRRK2	inhibits	gene	0.70
STING	activates	gene	0.70
STING	expressed_in	gene	0.70

Incoming (889)

Source	Relation	Type	Str
CYP46A1	inhibits	gene	0.70
BDNF	markers	gene	0.70
ACHE	regulates	gene	0.70
CHRNA7	regulates	gene	0.70
ATG5	mediates	gene	0.70
BDNF	expresses	gene	0.70
ATP13A2	associated_with	gene	0.70
COMT	regulates	gene	0.70
AQP4	causes	gene	0.65
BECN1	associated_with	gene	0.65
AIF1	associated_with	gene	0.65
ATG7	associated_with	gene	0.65
CASP1	associated_with	gene	0.65
ATG5	associated_with	gene	0.65
DRP1	activates	gene	0.60
AUTOPHAGY	mediates	pathway	0.60
ASTROCYTES	mediates	cell_type	0.60
ACHE	associated_with	gene	0.60
PYROPTOSIS	regulates	gene	0.60
AKT	protects_against	gene	0.60
MFN2	activates	gene	0.60
DNAJB1	inhibits	gene	0.60
ERK1/2	activates	gene	0.60
ASTROCYTE	mediates	cell_type	0.60
APOE	protects_against	gene	0.60
LYSOSOME	contributes_to	gene	0.60
ALZHEIMER	protects_against	gene	0.60
HUNTINGTON	encodes	gene	0.60
AUTOPHAGY	encodes	gene	0.60
MICROGLIA	expressed_in	gene	0.60
APP	activates	gene	0.60
GBA1	activates	gene	0.60
PKM2	activates	gene	0.60
AGING	contributes_to	gene	0.60
DNAJB6	inhibits	gene	0.60
PARKIN	inhibits	gene	0.60
DEPRESSION	activates	gene	0.60
SNAP25	interacts_with	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
OPA1	activates	gene	0.60
PARK2	activates	gene	0.60
USP30	activates	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
MFN1	activates	gene	0.60
LAMP2	contributes_to	gene	0.60
GBA1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
AKT	regulates	gene	0.60
MITOPHAGY	contributes_to	gene	0.60
UBIQUITIN	interacts_with	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi	0.783	neurodegeneration	-
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.751	neuroscience	Circuit-level neural dynamics in neurode
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9	0.750	neurodegeneration	-
Chronic ISR Activation Represses Axonal Protein Synthesis in	0.650	Parkinson's disease	-

Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.606	neurodegeneration	What are the mechanisms by which gut mic
Dopaminergic Ventral Tegmental-Striatal Circuit Protection	0.380	neuroscience	Circuit-level neural dynamics in neurode
TFEB Activation to Restore Lysosomal Biogenesis in Parkinson	0.380	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plasma ATN biomarkers across AD continuum in Chilean cohort	clinical	Alzheimer's disease	0.950	Chilean older adults (n=318) w	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	human patients	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	primary rodent neuronal cultur	proposed	N/A
Differential GWAS of schizophrenia vs PTSD	exploratory	schizophrenia, post-traumatic	0.900	human patients - European ance	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	primary rodent neuronal cultur	proposed	N/A
Creation and validation of 3xAD-ChAT-Cre mouse model	validation	Alzheimer's disease	0.900	3xAD-ChAT-Cre transgenic mice	proposed	N/A
GTEx brain tissue expression analysis of MAPT/CRHR1 locus	exploratory	schizophrenia, post-traumatic	0.850	human brain tissue samples fro	proposed	N/A
Microtubule domain analysis in adult axons	exploratory		0.800	adult rodent axons	proposed	N/A
Tau depletion effects on microtubule domains in adult axons	exploratory		0.800	adult rodent neurons	proposed	N/A

Related Papers (13)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128]	["Bolsewig K", "Bellomo G", "Hok-A-Hin Y	Nature medicine	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147]	["Bolsewig K", "Willemse E", "S\u00e1nch	Nature communications	2025
Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral ph [PMID:37573958]	["Montillot C", "Skutunova E", "Ayushma"	Neurobiology of disease	2023
Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neu [PMID:36692274]	["Motta C", "Assogna M", "Bonomi C", "Di	European journal of neurology	2023
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
DOPA Decarboxylase Modulates Tau Toxicity. [PMID:28751068]	["Kow R", "Sikkema C", "Wheeler J", "Wil	Biological psychiatry	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DOPAMINERGIC in their description or question text