gene

LATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

30Hypotheses

0Analyses

50Outgoing

47Incoming

10Experiments

0Debates

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🧬 Gene Info

Gene Symbol	late
Aliases	late
Associated Diseases	ALZHEIMER, ALZHEIMER'S
KG Connections	374 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE)

disease · 1837 words

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LATE (Limbic-Predominant Age-Related TDP-43 Encephalopathy)

disease · 1609 words

→

Pathway Diagram

graph TD
    LATE["LATE"] -->|"associated"| RAB7["RAB7"]
    style RAB7 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"associated"| RILP["RILP"]
    style RILP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -.->|"inhibits"| RGS6["RGS6"]
    style RGS6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"expressed in"| TREM2["TREM2"]
    style TREM2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -.->|"inhibits"| RAD51["RAD51"]
    style RAD51 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Tdp_43["Tdp-43"] -->|"implicated in"| LATE["LATE"]
    style Tdp_43 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CANCER["CANCER"] -->|"associated"| LATE["LATE"]
    style CANCER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    APOE["APOE"] -->|"associated"| LATE["LATE"]
    style APOE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    EIF2AK3["EIF2AK3"] -.->|"inhibits"| LATE["LATE"]
    style EIF2AK3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ERN1["ERN1"] -.->|"inhibits"| LATE["LATE"]
    style ERN1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style LATE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (481)

Target	Relation	Type	Str
UNC5C	associated_with	entity	0.60
NEUROINFLAMMATION	activates	entity	0.60
NEUROINFLAMMATION	associated_with	entity	0.60
NEURODEGENERATION	associated_with	entity	0.60
NEURODEGENERATION	activates	entity	0.60
RGS6	inhibits	entity	0.60
TREM2	expressed_in	entity	0.60
VPS4A	inhibits	entity	0.60
RAB7	associated_with	entity	0.60
RAD51	inhibits	entity	0.60
RILP	associated_with	entity	0.60
MTOR	activates	entity	0.60
NUCLEUS	associated_with	concept	0.50
TUMOR	associated_with	disease	0.50
INTERNEURONS	activates	concept	0.50
DEMENTIA	associated_with	gene	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
Tauopathy	activates	disease	0.50
NEURONS	activates	concept	0.50
CARCINOMA	activates	disease	0.50
Endocytosis	regulates	pathway	0.50
NETRIN-1	activates	protein	0.50
IMMUNE RESPONSE	expressed_in	pathway	0.50
Proteins	expressed_in	protein	0.50
Astrocytes	regulates	cell_type	0.50
NEURONS	inhibits	concept	0.50
inflammation	associated_with	pathway	0.50
CELL DEATH	inhibits	concept	0.50
ALZHEIMER'S	interacts_with	concept	0.50
AMYLOID	interacts_with	gene	0.50
disease	interacts_with	disease	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
Alzheimer'S Disease	regulates	disease	0.50
ALZHEIMER	regulates	gene	0.50
ALZHEIMER	interacts_with	gene	0.50
INTERNEURON	regulates	concept	0.50
Astrocyte	regulates	cell_type	0.50
ALZHEIMER'S	regulates	concept	0.50
INTERNEURONS	inhibits	concept	0.50
CYTOKINE	regulates	concept	0.50
INTERNEURON	inhibits	concept	0.50
Jak-Stat	regulates	pathway	0.50
Tdp-43	interacts_with	pathway	0.50
TAU PATHOLOGY	activates	concept	0.50
microglia	expressed_in	cell_type	0.50
HLA-DRB1	expressed_in	gene	0.50
apoptosis	activates	process	0.50
Endocytosis	expressed_in	pathway	0.50
TUMOR	activates	disease	0.50
NEURONS	associated_with	concept	0.50

Incoming (47)

Source	Relation	Type	Str
Tdp-43	implicated_in	protein	0.90
CANCER	associated_with	entity	0.60
APOE	associated_with	entity	0.60
APOE	upregulates	entity	0.60
EIF2AK3	inhibits	entity	0.60
ERN1	inhibits	entity	0.60
BIN1	associated_with	entity	0.60
AKT	activates	entity	0.60
APOE	expressed_in	entity	0.60
DEPRESSION	associated_with	entity	0.60
CANCER	activates	entity	0.60
GLAUCOMA	associated_with	gene	0.50
CD33	activates	gene	0.50
CD33	interacts_with	gene	0.50
CD33	expressed_in	gene	0.50
APOE4	associated_with	gene	0.50
LRRK2	interacts_with	gene	0.50
LRRK2	regulates	gene	0.50
LRRK2	activates	gene	0.50
Neuroinflammation	associated_with	process	0.50
TREM2	activates	gene	0.50
TREM2	inhibits	gene	0.50
TREM2	associated_with	gene	0.50
TYROBP	activates	gene	0.50
TREM2	expressed_in	gene	0.50
apoe2	interacts_with	disease	0.50
APOE3	interacts_with	protein	0.50
APOE4	interacts_with	gene	0.50
DEPRESSION	interacts_with	disease	0.50
DEPRESSION	associated_with	disease	0.50
Neuroinflammation	activates	process	0.50
DEPRESSION	activates	disease	0.50
LRRK2	causes	gene	0.50
LRRK2	associated_with	gene	0.50
PHAGOCYTOSIS	activates	gene	0.50
Neuroinflammation	interacts_with	process	0.50
P2RY12	co_discussed	gene	0.40
ABCD3	co_discussed	gene	0.40
ALZHEIMER DISEASE	co_discussed	gene	0.40
RELA	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
SPP1	co_discussed	gene	0.40
MICROGLIA	co_discussed	cell_type	0.40
SYNA	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
MYOT	co_discussed	gene	0.40
NEURON	co_discussed	gene	0.40

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.921	neurodegeneration	Lipid raft composition changes in synapt
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.754	molecular neurobiology	View
Near-infrared light therapy stimulates COX4-dependent mitoch	0.742	neurodegeneration	Mitochondrial transfer between astrocyte
TREM2 haploinsufficiency dysregulates microglial synaptic su	0.700	neurodegeneration	Synaptic pruning by microglia in neurode

LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Radiation drives pericyte senescence through lysosome acidif	0.652	neurodegeneration	What specific autophagy pathways are def
TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs	0.650	neurodegeneration	What determines P2RY12 receptor expressi
Liver-Derived Inflammatory Suppressors Downregulate Microgli	0.633	neuroinflammation	What causes IBA1 low/negative microglia
Layer V excitatory neurons show selectively enhanced vulnera	0.632	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracell	0.630	neurodegeneration	Investigate prion-like spreading of tau
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.628	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Microglial TREM2 downregulation impairs damage-associated re	0.628	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
H7: Aberrant RNA Template Switching Converts Granules to Agg	0.625	neurodegeneration	How do pathological stress granules tran
Basal forebrain NGF/TrkA trophic failure is an upstream trig	0.610	neurodegeneration	What determines the temporal sequence of
Female microglia exhibit heightened complement gene expressi	0.610	neurodegeneration	Synaptic pruning by microglia in neurode
Glycosaminoglycan Template Disruption Approach	0.597	neurodegeneration	Protein aggregation cross-seeding across
Dysregulated G3BP1 Signaling Impairs Local Translation in Ne	0.580	neurodegeneration	How do disease-associated mutations in G
TBK1 Phosphorylation State Creates Phospho-Regulated Periphe	0.577	neurodegeneration	What determines the spatial organization
H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Rever	0.577	neurodegeneration	How do pathological stress granules tran
Epigenetic Reprogramming Required for Late-Stage Interventio	0.542	neurodegeneration	What is the optimal therapeutic window f
P2Y6R activation by UDP from damaged neurons drives microgli	0.540	neurodegeneration	Which tau propagation mechanism predomin
Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Ta	0.520	neurodegeneration	Investigate prion-like spreading of tau
HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp	0.520	neurodegeneration	Investigate mechanisms of epigenetic rep
Dysregulated microglial glycolysis via HIF1α activation shif	0.520	neurodegeneration	Synaptic pruning by microglia in neurode
Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement F	0.518	synaptic biology	Does SPP1-mediated synaptic engulfment r
Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Com	0.510	neurodegeneration	Investigate mechanisms of epigenetic rep
GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates v	0.491	neuroscience	Circuit-level neural dynamics in neurode
Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple	0.487	neurodegeneration	How do pathological stress granules in n
TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signat	0.483	-	Epigenetic clocks as biomarkers for Alzh

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso	validation	Parkinson's Disease	0.400	0.50	human	proposed	$3,000,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Cytochrome Therapeutics	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Peroxisomal Dysfunction Validation in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Prodromal Parkinson's Disease Biomarker Development — Early Detection	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response	clinical	Neurodegeneration	0.400	0.50	human	proposed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. [PMID:32722981]	Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W	Autophagy	2021	1
SIRT5 regulation of ammonia-induced autophagy and mitophagy. [PMID:25700560]	Polletta L, Vernucci E, Carnevale I, Arc	Autophagy	2015	1
PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via t [PMID:41612594]	Chen K, Zhang Y, Ruan H, Wei Z, Wang K,	Autophagy	2026	0
ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818]	["Li X", "Huang J", "Zhou Y", "Chen X",	International journal of pharm	2026	0
Single-Cell RNA Sequencing and Network Pharmacology Reveal the Potential Role of [PMID:41610872]	["Niu J", "Wang L", "Qi J", "Lu G"]	The journal of gene medicine	2026	0
Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female R [PMID:41600627]	Bai J, Li J, Tang L, Sun W, Gao F, Zhang	Toxics	2026	0
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026	0
Functional and Molecular Characterization of Melamine-Induced Disruption of Huma [PMID:41596180]	["Luongo F", "Annunzi E", "Ponchia R", "	Antioxidants (Basel, Switzerla	2026	0
Exploring the lactate-metabolism related characteristics during the development [PMID:41815173]	Wang C, Zhang R, Li S, Kang Z, Xia S, Li	Translational cancer research	2026	0
Developmental toxicity of carboxylated microplastics in zebrafish mediated by mi [PMID:41265820]	["Li Y", "Ni Y", "Dong C", "Zhang J", "G	Environmental pollution (Barki	2026	0
Complex IV deficiency due to COX4I1 deep intronic and de novo variants results i [PMID:41203052]	Ugarteburu O, Farré-Tarrats L, Muñoz-Puj	Mitochondrion	2026	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
810-nm Photobiomodulation Evokes Glutamate Release in Normal and Rotenone-Dysfun [PMID:39851493]	["Ravera S", "Farsetti E", "Maura G", "M	Cells	2025	0
Mongolian medicine Wulanwendusu-11 alleviates myocardial ischemia-reperfusion in [PMID:41586357]	["Wuyunsiqin", "Bai T", "Yang D", "Hashe	Frontiers in microbiology	2025	0
Near-Infrared Photoimmunotherapy in Brain Tumors-An Unexplored Frontier. [PMID:40430568]	["Yamaguchi H", "Okada M", "Otani T", "O	Pharmaceuticals (Basel, Switze	2025	0
Evaluation of local and systemic photobiomodulation in only single-implant inser [PMID:40531278]	["Pucca D", "Pinheiro S"]	Oral and maxillofacial surgery	2025	0
Comparison of the efficacy of 12 interventions in the treatment of diabetic foot [PMID:40821981]	["Hu X", "Meng H", "Liang J", "An H", "Z	PeerJ	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Dose-dependent effects of transcranial photobiomodulation on brain temperature i [PMID:39370461]	["Weerasekera A", "Coelho D", "Ratai E",	Lasers in medical science	2024	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LATE in their description or question text

LPS-primed microglial trained immunity establishes persistent H3K4me3 landscapes

Score: 0.670 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The molecular foundation of this hypothesis centers on the concept of trained imm

Radiation drives pericyte senescence through lysosome acidification failure and

Score: 0.652 · neurodegeneration · 2026-04-25

Autophagosomes still form after irradiation, but damaged lysosomes cannot clear cargo, sustaining ROS and SASP output.

TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs

Score: 0.650 · neurodegeneration · 2026-04-21

## Mechanistic Overview TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs starts from the claim that modulating RELA (p65), I

Liver-Derived Inflammatory Suppressors Downregulate Microglial IBA1

Score: 0.633 · neuroinflammation · 2026-04-21

## Mechanistic Overview Liver-Derived Inflammatory Suppressors Downregulate Microglial IBA1 starts from the claim that m

Layer V excitatory neurons show selectively enhanced vulnerability through dysre

Score: 0.632 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Layer V excitatory neurons show selectively enhanced vulnerability through dysregulated calcium

CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Prev

Score: 0.630 · neurodegeneration · 2026-04-22

## Mechanistic Overview CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Preventing Template-

TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinflammatory Amplificat

Score: 0.628 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinflammatory Amplification starts from

Microglial TREM2 downregulation impairs damage-associated response in late-stage

Score: 0.628 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's dis

H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone

Score: 0.625 · neurodegeneration · 2026-04-22

## Mechanistic Overview H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone starts from the claim

Basal forebrain NGF/TrkA trophic failure is an upstream trigger that makes choli

Score: 0.610 · neurodegeneration · 2026-04-25

Loss of retrograde NGF-TrkA support could destabilize basal-forebrain cholinergic neurons early, lowering cortical acety

Female microglia exhibit heightened complement gene expression and pruning capac

Score: 0.610 · neurodegeneration · 2026-04-22

## Mechanistic Overview Female microglia exhibit heightened complement gene expression and pruning capacity via estrogen

Glycosaminoglycan Template Disruption Approach

Score: 0.597 · neurodegeneration · 2026-04-02

Heparan sulfate and other glycosaminoglycans serve as nucleation templates that facilitate cross-seeding by concentratin

Dysregulated G3BP1 Signaling Impairs Local Translation in Neuronal Processes, Co

Score: 0.580 · neurodegeneration · 2026-04-22

## Mechanistic Overview Dysregulated G3BP1 Signaling Impairs Local Translation in Neuronal Processes, Contributing to Sy

TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Thresh

Score: 0.577 · neurodegeneration · 2026-04-21

## Mechanistic Overview TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Threshold starts from

H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Reversibility

Score: 0.577 · neurodegeneration · 2026-04-22

## Mechanistic Overview H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Reversibility starts from the claim that