gene

WDR45

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDR45: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

251Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

WDR45 is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, activates. Associated with Als, Amyotrophic Lateral Sclerosis, BPAN. Connected to 126 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WDR45
Full Name	WD Repeat Domain 45
Aliases	Page for WDR45, WIPR1
Chromosome	Xp11.23<br/>
Function	WDR45 (also called WIPR1) participates in autophagy
Primary Expression	neuronal tissues:
Molecular Weight	39 kDa
Pathways	mTOR, mtor
UniProt ID	Q9Y5X9
NCBI Gene ID	11152
Ensembl ID	ENSG00000196998
GeneCards	WDR45
Human Protein Atlas	WDR45
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, BPAN, brain iron accumulation, Cancer
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AMYLOID, AR, ATF6, ATG, ATG2A
KG Connections	251 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WDR45 — AlphaFold Q9Y5X9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WDR45["WDR45"]
    WDR45 -->|"binds"| Caprin_1["Caprin-1"]
    WDR45 -->|"participates in"| autophagy["autophagy"]
    WDR45 -->|"causes"| ER_stress["ER stress"]
    WDR45 -->|"causes"| neuronal_apoptosis["neuronal apoptosis"]
    WDR45 -->|"causes"| neurodegeneration["neurodegeneration"]
    WDR45 -->|"causes"| brain_iron_accumulation["brain iron accumulation"]
    WDR45 -->|"causes"| intellectual_disability["intellectual disability"]
    WDR45 -->|"encodes"| WIPI4["WIPI4"]
    WDR45 -->|"regulates"| Cancer["Cancer"]
    WDR45 -->|"regulates"| Cardiovascular["Cardiovascular"]
    biotin["biotin"] -->|"upregulates"| WDR45
    MTOR["MTOR"] -->|"regulates"| WDR45
    ATG["ATG"] -->|"regulates"| WDR45

Outgoing (129)

Target	Relation	Type	Str
BPAN	causes	disease	0.95
Macroautophagy	regulates	process	0.90
Caprin-1	binds	protein	0.90
ER Homeostasis	regulates	process	0.85
brain iron accumulation	causes	phenotype	0.80
intellectual disability	causes	disease	0.80
ER stress	causes	biological_process	0.80
neurodegeneration	causes	disease	0.80
neuronal apoptosis	causes	biological_process	0.80
Neurodegeneration	associated_with	disease	0.75
oxidative stress response	participates_in	pathway	0.70
BPAN	associated_with	disease	0.70
WIPI4	encodes	protein	0.70
Dystonia	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Ischemia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Amyloid Beta	associated_with	protein	0.60
ALS	interacts_with	disease	0.60
Cathepsin	associated_with	protein	0.60
stem cells	expressed_in	cell_type	0.60
autism spectrum disorder	activates	disease	0.60
Mtor	associated_with	pathway	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
GLA	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
neurodegeneration	regulates	disease	0.60
ALS	associated_with	disease	0.60
G3BP1	activates	gene	0.60
SOX9	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60

Incoming (122)

Source	Relation	Type	Str
biotin	upregulates	chemical	0.80
NEURODEGENERATION	associated_with	gene	0.70
SQSTM1	implicated_in	gene	0.60
P62	implicated_in	gene	0.60
UBIQUITIN	implicated_in	gene	0.60
WIPI4	regulates	gene	0.60
BPAN	causes	entity	0.60
G3BP1	activates	gene	0.60
AMPK	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
ATG	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
ATP6AP2	associated_with	gene	0.60
RAS	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
AXON	implicated_in	gene	0.60
NEURODEGENERATION	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
GFP	activates	gene	0.60
MITOCHONDRIA	causes	gene	0.60
WIPI4	associated_with	gene	0.60
DNA	activates	gene	0.60
RNA	causes	gene	0.60
PANK2	interacts_with	gene	0.60
PLA2G6	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
FTL	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WDR45 in their description or question text

No additional research found