gene 980 words KG: WDR45
Contents

WDR45 - WD Repeat Domain 45

🧬 Gene Info
Gene SymbolWDR45
Full NameWD Repeat Domain 45
AliasesPage for WDR45, WIPR1
ChromosomeXp11.23<br/>
FunctionWDR45 (also called WIPR1) participates in autophagy
Primary Expressionneuronal tissues:
Molecular Weight39 kDa
PathwaysmTOR, mtor
UniProt IDQ9Y5X9
NCBI Gene ID11152
Ensembl IDENSG00000196998
GeneCardsWDR45
Human Protein AtlasWDR45
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, BPAN, brain iron accumulation, Cancer
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AMYLOID, AR, ATF6, ATG, ATG2A
KG Connections248 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

APOE-Dependent Autophagy Restoration
Score: 0.89
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Extracellular Matrix Stiffness Modulation
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Wilson Disease Neurodegeneration: Mechanism and Therapeutic
clinical · proposed · Score: 0.40

See Also (9)

blarcamesine-axon
clinical_trial · KG edge: implicated_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
AMBRA1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ULK1 associated_with WDR45
BCL2 associated_with WDR45
RAB9A associated_with WDR45
BCL2L1 associated_with WDR45
GLA associated_with WDR45
GABARAP associated_with WDR45
PSEN2 associated_with WDR45
CTSD associated_with WDR45
FYCO1 associated_with WDR45
LAMP2 associated_with WDR45

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