| Gene Symbol | WDR45B |
| Full Name | WD Repeat Domain 45B |
| Aliases | WDR45B Protein |
| Function | is a WD repeat protein that plays a critical role in autophagy, specifically in the formation and function of autophagosomes. |
| Primary Expression | the brain [@toney2019] |
| Subcellular Localization | </th><td>Cytoplasm, Autophagosomes, Endoplasmic Reticulum</td></tr> |
| Molecular Weight | 44.6 kDa |
| Pathways | PI3K |
| Ensembl ID | ENSG00000160087 |
| GeneCards | WDR45B |
| Human Protein Atlas | WDR45B |
| ATG14/Barkor | Component of the PI3K complex I |
| ULK1 Complex | Upstream autophagy initiator |
| LC3/GABARAP | Autophagosomal marker proteins |
| Autophagosome Formation | WDR45B localizes to the ER-mitochondria contact sites and phagophore assembly sites, facilitating the recruitment of ATG proteins<sup>[3]</sup>. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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