gene

WIPI4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

34Outgoing

34Incoming

0Experiments

0Debates

Summary

WIPI4 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, causes. Associated with Als, Ms, Neurodegeneration. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WIPI4
Chromosome	19p13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	44 kDa
Amino Acids	371 aa
Pathways	Autophagy
UniProt ID	Q9N5Z0
NCBI Gene ID	162317
Ensembl ID	ENSG00000168096
OMIM	614402
GeneCards	WIPI4
Human Protein Atlas	WIPI4
Associated Diseases	Als, Ms, Neurodegeneration
Interactions	AND, ATG, ATG16L1, atg2a, ATG2A, AUTOPHAGY
KG Connections	68 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WIPI4 — AlphaFold Q9N5Z0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WIPI4 Gene

gene · 1196 words

→

WIPI4 Protein

protein · 604 words

→

Pathway Diagram

graph TD
    WIPI4["WIPI4"]
    ferroptosis["ferroptosis"]
    WIPI4 -->|"causes"| ferroptosis
    AUTOPHAGY["AUTOPHAGY"]
    WIPI4 -->|"participates in"| AUTOPHAGY
    ATG2A["ATG2A"]
    WIPI4 -->|"interacts with"| ATG2A
    autophagy(["autophagy"])
    WIPI4 -->|"regulates"| autophagy
    WIPI4 -->|"regulates"| ferroptosis
    Ms{"Ms"}
    WIPI4 -->|"associated with"| Ms
    Neurodegeneration{"Neurodegeneration"}
    WIPI4 -->|"associated with"| Neurodegeneration
    WIPI1["WIPI1"]
    WIPI4 -->|"activates"| WIPI1
    LC3["LC3"]
    WIPI4 -->|"activates"| LC3
    Autophagy(["Autophagy"])
    WIPI4 -->|"regulates"| Autophagy
    WDR45["WDR45"]
    WIPI4 -->|"associated with"| WDR45
    MITOCHONDRIA["MITOCHONDRIA"]
    WIPI4 -->|"activates"| MITOCHONDRIA
    WDR45 -->|"encodes"| WIPI4
    ERK["ERK"]
    ERK -->|"activates"| WIPI4
    ATG16L1["ATG16L1"]
    ATG16L1 -->|"activates"| WIPI4
    ATG["ATG"]
    ATG -->|"activates"| WIPI4
    MYC["MYC"]
    MYC -->|"activates"| WIPI4
    GABARAP["GABARAP"]
    GABARAP -->|"activates"| WIPI4
    AUTOPHAGY -->|"regulates"| WIPI4
    WIPI3["WIPI3"]
    WIPI3 -->|"regulates"| WIPI4
    WIPI2["WIPI2"]
    WIPI2 -->|"activates"| WIPI4
    AMPK["AMPK"]
    AMPK -->|"regulates"| WIPI4
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| WIPI4
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"activates"| WIPI4
    style WIPI4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Ferroptosis	inhibits	process	0.92
ATG2A	regulates	protein	0.88
Autophagy	involved_in	pathway	0.85
ATG2A	interacts_with	protein	0.80
ferroptosis	regulates	process	0.70
Autophagy	regulates	pathway	0.70
autophagy	regulates	process	0.70
Ms	associated_with	disease	0.65
Neurodegeneration	causes	disease	0.65
Als	implicated_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
WDR45	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
autophagy pathway	participates_in	pathway	0.60
WIPI1	activates	gene	0.60
LC3	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Ferroptosis	causes	pathway	0.60
Autophagy	causes	pathway	0.60
AND	activates	gene	0.60
FERROPTOSIS	causes	gene	0.60
ferroptosis	participates_in	pathway	0.60
neurodegeneration	interacts_with	disease	0.60
MITOCHONDRIA	activates	gene	0.60
Raf	activates	protein	0.60
NEURODEGENERATION	causes	gene	0.60
WDR45	associated_with	gene	0.60
ATG2A	activates	gene	0.60
WDR45	regulates	gene	0.60
CELL DEATH	activates	concept	0.50
ferroptosis	activates	phenotype	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50

Incoming (34)

Source	Relation	Type	Str
WDR45	encodes	gene	0.70
AUTOPHAGY	regulates	gene	0.70
WDR45	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ERK	activates	gene	0.60
ATG	activates	gene	0.60
AXON	regulates	gene	0.60
ATG2A	activates	gene	0.60
BPAN	causes	entity	0.60
WDR45	causes	entity	0.60
BPAN	degrades	entity	0.60
FERROPTOSIS	activates	gene	0.60
UBIQUITIN	implicated_in	gene	0.60
SQSTM1	implicated_in	gene	0.60
P62	implicated_in	gene	0.60
ATG16L1	activates	gene	0.60
MYC	activates	gene	0.60
GABARAP	activates	gene	0.60
WIPI3	regulates	gene	0.60
WIPI2	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
MITOCHONDRIA	activates	gene	0.60
bpan	causes	disease	0.50
bpan	associated_with	disease	0.50
Neurodegeneration	causes	disease	0.50
atg2a	activates	gene	0.50
Autophagy	causes	process	0.50
Autophagy	associated_with	process	0.50
Autophagy	activates	process	0.50
ferroptosis	co_mentioned	pathway	0.40
autophagy	co_mentioned	pathway	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WIPI4 in their description or question text

No additional research found