gene

PANK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PANK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

25Outgoing

12Incoming

0Experiments

0Debates

Summary

PANK2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Aging, Als, Dystonia. Connected to 28 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PANK2
Full Name	Pantothenate Kinase 2
Chromosome	20p13
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	High in brain, especially basal ganglia
Subcellular Localization	the mitochondrial matrix. It catalyzes the first and rate-limiting step in CoA biosynthesis, the phosphorylation of vita
Molecular Weight	57 kDa
Amino Acids	570 aa
UniProt ID	Q9C0B0
NCBI Gene ID	80025
Ensembl ID	ENSG00000125779
OMIM	606157
GeneCards	PANK2
Human Protein Atlas	PANK2
Associated Diseases	Aging, Als, Dystonia, Ms, neurodegeneration
Interactions	ATP13A2, CP, DCAF17, FA2H, FTL, PLA2G6
KG Connections	37 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PANK2 — AlphaFold Q9C0B0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PANK2 — Pantothenate Kinase 2

gene · 1130 words

→

PANK2 Protein (Pantothenate Kinase 2)

protein · 687 words

→

Pathway Diagram

graph TD
    PANK2["PANK2"]
    pantothenate_kinase_associated_neurodege{"pantothenate kinase-associated neurodegeneration"}
    PANK2 -->|"associated with"| pantothenate_kinase_associated_neurodege
    Neurodegeneration{"Neurodegeneration"}
    PANK2 -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    PANK2 -->|"associated with"| Ms
    Als{"Als"}
    PANK2 -->|"associated with"| Als
    Parkinson{"Parkinson"}
    PANK2 -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    PANK2 -->|"associated with"| Dystonia
    Aging{"Aging"}
    PANK2 -->|"therapeutic target"| Aging
    PANK2 -->|"therapeutic target"| Als
    PLA2G6["PLA2G6"]
    PANK2 -->|"associated with"| PLA2G6
    Lipid_Metabolism(["Lipid Metabolism"])
    PANK2 -->|"associated with"| Lipid_Metabolism
    Mitophagy(["Mitophagy"])
    PANK2 -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    PANK2 -->|"associated with"| Autophagy
    AKT["AKT"]
    AKT -->|"regulates"| PANK2
    PLA2G6 -->|"associated with"| PANK2
    FTL["FTL"]
    FTL -->|"associated with"| PANK2
    WDR45["WDR45"]
    WDR45 -->|"associated with"| PANK2
    COASY["COASY"]
    COASY -->|"associated with"| PANK2
    DCAF17["DCAF17"]
    DCAF17 -->|"associated with"| PANK2
    FA2H["FA2H"]
    FA2H -->|"associated with"| PANK2
    C19ORF12["C19ORF12"]
    C19ORF12 -->|"associated with"| PANK2
    style PANK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Pantothenate Kinase-Associated Neurodegeneration	causes	disease	0.95
Neurodegeneration	associated_with	disease	0.85
NEURODEGENERATION	associated_with	gene	0.70
PLA2G6	associated_with	gene	0.70
pantothenate kinase-associated neurodegeneration	associated_with	disease	0.70
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
DNA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALS	associated_with	disease	0.60
neurodegeneration	interacts_with	disease	0.60
PLA2G6	interacts_with	gene	0.60
WDR45	interacts_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
MAX	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60

Incoming (12)

Source	Relation	Type	Str
ATP13A2	interacts_with	gene	0.60
CP	interacts_with	gene	0.60
DCAF17	interacts_with	gene	0.60
FA2H	interacts_with	gene	0.60
FTL	interacts_with	gene	0.60
PLA2G6	associated_with	gene	0.60
FTL	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
COASY	associated_with	gene	0.60
DCAF17	associated_with	gene	0.60
FA2H	associated_with	gene	0.60
C19ORF12	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PANK2 in their description or question text

No additional research found