gene

PLA2G6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLA2G6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

PLA2G6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, co discussed, activates. Associated with ALS, Aging, Als. Connected to 63 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLA2G6
Full Name	PLA2G6 (iPLA2-VI)
Aliases	iPLA2-VI
Chromosome	22q13.1
Protein Type	Enzyme
Target Class	Enzyme
Function	Phospholipid remodeling - generates lysophospholipids and free fatty acids
Mechanism of Action	Small molecule inhibitor of calcium-independent phospholipase A2 activity
Subcellular Localization	mitochondrial membranes where it regulates phospholipid composition and supports mitochondrial function. Loss of enzyme
Druggability	Low (0.36)
Clinical Stage	Approved
Molecular Weight	90 kDa
Amino Acids	752 aa
Pathways	Cellular senescence / SASP signaling, Ros
UniProt ID	Q9NP81
GeneCards	PLA2G6
Human Protein Atlas	PLA2G6
Associated Diseases	Als, Alzheimer, Dystonia, Ms
Known Drugs/Compounds	BEL
Interactions	AND, APOPTOSIS, ATP13A2, BRAIN INJURY, C1Q, CP
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	220 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PLA2G6 — AlphaFold Q9NP81 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLA2G6["PLA2G6"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PLA2G6["PLA2G6"] -->|"interacts"| PLA2G4A["PLA2G4A"]
    PLA2G6["PLA2G6"] -->|"co discussed"| MMP2["MMP2"]
    PLA2G6["PLA2G6"] -->|"co discussed"| C3["C3"]
    PLA2G6["PLA2G6"] -->|"co discussed"| PLA2G4A_1["PLA2G4A"]
    PLA2G6["PLA2G6"] -->|"co discussed"| IL1B["IL1B"]
    PLA2G4A_2["PLA2G4A"] -->|"interacts"| PLA2G6["PLA2G6"]
    MMP9["MMP9"] -->|"co discussed"| PLA2G6["PLA2G6"]
    SLC7A11["SLC7A11"] -->|"co discussed"| PLA2G6["PLA2G6"]
    AQP4["AQP4"] -->|"co discussed"| PLA2G6["PLA2G6"]
    style PLA2G6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (131)

Target	Relation	Type	Str
Phospholipase A2 Group VI-Associated Neurodegeneration	causes	disease	0.95
arachidonic acid	associated_with	compound	0.90
neurodegeneration	interacts_with	disease	0.80
neurodegeneration	causes	disease	0.80
demyelination	associated_with	process	0.80
myelin lipids	modifies	structure	0.80
Schizophrenia	risk_factor_for	disease	0.78
neurodegeneration	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
SYNJ1	associated_with	gene	0.70
GENES	associated_with	gene	0.70
VPS13C	associated_with	gene	0.70
Parkinson's disease	causes	disease	0.70
Parkinson's disease	interacts_with	disease	0.70
Parkinson	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
BRAIN INJURY	activates	gene	0.60
PLA2G3	activates	gene	0.60
STROKE	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
Epigenetic	activates	pathway	0.60
PLA2G12F	activates	gene	0.60
PLA2G4F	activates	gene	0.60
PLA2G4A	activates	gene	0.60
PLA2G4A	inhibits	gene	0.60
PANK2	associated_with	gene	0.60
MAX	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
Interferon	inhibits	protein	0.60
neurons	associated_with	cell_type	0.60
neurons	disrupts	cell_type	0.60
Parkinson's disease	disrupts	disease	0.60
Parkinson's disease	associated_with	disease	0.60
ALZHEIMER	associated_with	disease	0.60

Incoming (89)

Source	Relation	Type	Str
h-bb518928	targets	hypothesis	0.90
BEL	inhibits	drug	0.85
oxidized phosphatidylcholines	causes	chemical	0.80
DOPAMINERGIC	associated_with	cell_type	0.70
TREM2	upregulates	gene	0.70
PANK2	associated_with	gene	0.70
COASY	associated_with	gene	0.60
DCAF17	associated_with	gene	0.60
FA2H	associated_with	gene	0.60
C19ORF12	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
FTL	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
MECP2	associated_with	entity	0.60
HDAC3	activates	gene	0.60
MECP2	inhibits	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
PLA2G4A	associated_with	gene	0.60
PLA2G4A	activates	gene	0.60
PLA2G4A	inhibits	gene	0.60
ATP1A3	associated_with	gene	0.60
FTL	interacts_with	gene	0.60
PLA2G3	activates	gene	0.60
CP	interacts_with	gene	0.60
DCAF17	interacts_with	gene	0.60
apoptosis	binds_to	pathway	0.60
FA2H	interacts_with	gene	0.60
ATXN2	associated_with	gene	0.60
PANK2	interacts_with	gene	0.60
ATP13A2	interacts_with	gene	0.60
DNAJC6	interacts_with	gene	0.60
FBXO7	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
GENES	inhibits	gene	0.60
BRAIN INJURY	activates	gene	0.60
PD	associated_with	gene	0.60
PD	co_discussed	gene	0.60
PLA2G4A	upregulates	entity	0.60
PLA2G4A	regulates	entity	0.60
PLA2G4A	expressed_in	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.984

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PLA2G6 in their description or question text

No additional research found

PLA2G6

Understanding Entity Pages

Summary

Wiki Pages (5)

Infantile Neuroaxonal Dystrophy (INAD) Pathway

PLA2G6 Protein

PLA2G6-Associated Neurodegeneration (PLAN)

PLA2G6 — Phospholipase A2 Group VI

PLA2G6 Protein (iPLA2-VI)