gene

GAK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

18Outgoing

11Incoming

0Experiments

0Debates

Summary

Cyclin G-associated kinase (GAK), a serine/threonine kinase involved in endocytosis, autophagy, and neurodegeneration

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🧬 Gene Info

Gene Symbol	GAK
Chromosome	6p21.1.
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase encoded by the GAK gene on chromosome 6p21.
Molecular Weight	165 kDa
Amino Acids	505 aa
Exons	43
Pathways	mTOR
GeneCards	GAK
Human Protein Atlas	GAK
N-terminal kinase domain	Serine/threonine kinase activity
Central clathrin-binding domain	Mediates interaction with clathrin-coated pits
C-terminal Hsc70-binding domain	Regulates chaperone-mediated protein folding
Associated Diseases	Als, Ms, Parkinson
KG Connections	29 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GAK Gene

gene · 697 words

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GAK Protein

protein · 1284 words

→

Pathway Diagram

graph TD
    GAK["GAK"]
    Parkinson{"Parkinson"}
    GAK -->|"associated with"| Parkinson
    Als{"Als"}
    GAK -->|"associated with"| Als
    Ms{"Ms"}
    GAK -->|"associated with"| Ms
    SYNJ1["SYNJ1"]
    GAK -->|"associated with"| SYNJ1
    AUTOPHAGY["AUTOPHAGY"]
    GAK -->|"associated with"| AUTOPHAGY
    DNAJC6["DNAJC6"]
    GAK -->|"associated with"| DNAJC6
    GENE_MUTATIONS["GENE MUTATIONS"]
    GAK -->|"associated with"| GENE_MUTATIONS
    PARK2["PARK2"]
    GAK -->|"associated with"| PARK2
    Autophagy(["Autophagy"])
    GAK -->|"associated with"| Autophagy
    Endocytosis(["Endocytosis"])
    GAK -->|"associated with"| Endocytosis
    neurodegeneration["neurodegeneration"]
    GAK -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| GAK
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| GAK
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| GAK
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| GAK
    INPP5F["INPP5F"]
    INPP5F -->|"associated with"| GAK
    style GAK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
SNCA	associated_with	gene	0.60
SYNJ1	associated_with	gene	0.60
ALZHEIMER DISEASE	expressed_in	gene	0.60
DNAJC6	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
GBA	associated_with	gene	0.60
HLA	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Endocytosis	associated_with	pathway	0.60
GENE MUTATIONS	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
DGKQ	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
ALPHA-SYNUCLEIN	associated_with	gene	0.60
INPP5F	associated_with	gene	0.60
PARKINSON	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
PARKIN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
FOXO1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAK in their description or question text

No additional research found