gene 2,524 words KG: PARK2
Contents

PARK2 - Parkin

🧬 Gene Info
Gene SymbolPARK2
Full NameParkin
Chromosome6q26
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight52 kDa
Amino Acids465 aa
Exons12
PathwaysApoptosis, Immune Response, Mitophagy
Ensembl IDENSG00000185345
GeneCardsPARK2
Human Protein AtlasPARK2
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compoundslevodopa, THSG
InteractionsAGING, ALS, AND, APOPTOSIS, AR, ATG5
KG Connections478 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
VCP-Mediated Autophagy Enhancement
Score: 0.59
APOE-Dependent Autophagy Restoration
Score: 0.88
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
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Related Analyses (9)

Does TRPML1 enhancement cause therapeutic benefit or paradox
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (6)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: activates
ATG7 Gene
gene · KG edge: associated_with
ATM Gene
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

GABARAP activates PARK2
GABARAPL2 activates PARK2
SIRT5 activates PARK2
BNIP3 activates PARK2
PINK1 activates PARK2
PARK2 activates MAP1LC3B
PARKIN associated_with PARK2
BCL2L13 associated_with PARK2
TOMM20 associated_with PARK2
ATG7 associated_with PARK2

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