| Gene Symbol | PARK2 |
| Aliases | PARKINPROTEIN |
| Chromosome | 6q26 |
| Protein Type | Ligase |
| Function | Parkin is a cytosolic E3 ubiquitin ligase essential for mitochondrial maintenance and quality control. |
| Primary Expression | AD brain - Parkin can degrade amyloid precursor protein (APP) fragments - May affect tau phosphorylation through ubiquitin-dependent pathways[@burns20 |
| Subcellular Localization | </strong></td><td>Cytoplasm, Mitochondria outer membrane</td></tr> |
| Pathways | Adaptive Immunity, Amyloid, Apoptosis, Autophagy, Cell Cycle |
| UniProt ID | O60260 |
| NCBI Gene ID | 5071 |
| Ensembl ID | ENSG00000185358 |
| GeneCards | PARK2 |
| Human Protein Atlas | PARK2 |
| Regulation of mitochondrial dynamics | Controls mitochondrial fusion/fission balance through ubiquitination of fusion proteins |
| Transcriptional regulation | Modulates expression of PGC-1α and mitochondrial biogenesis genes |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Canagliflozin, curcumin, CURCUMIN, DEFERIPRONE, EMPAGLIFLOZIN, epigallocatechin gallate |
| Interactions | 6-OHDA, ABCD3, ACAT1, ACETYL-COA, Actin, AGING |
| KG Connections | 2716 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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