gene

BAD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

491Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for BAD Gene - BCL2-Associated Agonist of Cell Death

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🧬 Gene Info

Gene Symbol	BAD
Aliases	Page for BAD Gene
Chromosome	11q13.1
Function	BAD is a BH3-only pro-apoptotic BCL-2 family member
Pathways	Apoptosis, Differentiation, Er Stress, Immune Response, Synaptic Plasticity
UniProt ID	Q92934
NCBI Gene ID	573
GeneCards	BAD
Human Protein Atlas	BAD
Associated Diseases	AD, Als, Alzheimer, Cancer, fibrosis
Interactions	AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, AMPK
KG Connections	491 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BAD — AlphaFold Q92934 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BAD Gene - BCL2-Associated Agonist of Cell Death

gene · 587 words

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Pathway Diagram

flowchart TD
    BAD["BAD
(BCL2 Associated
Agonist of Cell Death)"]
    
    BAD -->|"activates"| APOP["Apoptosis
Cell Death"]
    BAD -->|"associated_with"| FERRO["Ferroptosis
Iron-dependent
Cell Death"]
    BAD -->|"regulates"| ISCH["Ischemic
Damage"]
    BAD -->|"associated_with"| NEUROINF["Neuroinflammation"]
    
    APOP -->|"contributes_to"| ALS["ALS
(Motor Neuron
Degeneration)"]
    APOP -->|"contributes_to"| PD["Parkinson's
Disease"]
    APOP -->|"contributes_to"| AD["Alzheimer's
Disease"]
    APOP -->|"contributes_to"| MS["Multiple
Sclerosis"]
    
    FERRO -->|"promotes"| NEURODEGENERATION["Neurodegeneration"]
    NEUROINF -->|"accelerates"| NEURODEGENERATION
    ISCH -->|"triggers"| NEURODEGENERATION
    
    BAD -->|"therapeutic_target"| ALS_THERAPY["ALS Therapy
Development"]
    BAD -->|"therapeutic_target"| PD_THERAPY["Parkinson's
Therapy"]
    BAD -->|"therapeutic_target"| AD_THERAPY["Alzheimer's
Therapy"]
    BAD -->|"therapeutic_target"| MS_THERAPY["MS Therapy
Development"]
    
    BAD -->|"inhibits"| TUMOR["Tumor
Formation"]
    BAD -->|"inhibits"| CANCER["Cancer
Progression"]
    
    style BAD fill:#006494
    style ALS_THERAPY fill:#1b5e20
    style PD_THERAPY fill:#1b5e20
    style AD_THERAPY fill:#1b5e20
    style MS_THERAPY fill:#1b5e20
    style APOP fill:#ef5350
    style FERRO fill:#ef5350
    style NEUROINF fill:#ef5350
    style NEURODEGENERATION fill:#5d4400
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style AD fill:#5d4400
    style MS fill:#5d4400

Outgoing (369)

Target	Relation	Type	Str
apoptosis	activates	phenotype	0.90
apoptosis	promotes	process	0.85
Als	therapeutic_target	disease	0.85
Apoptosis	associated_with	process	0.80
BAX	interacts_with	protein	0.80
Skin Fibrosis	associated_with	phenotype	0.80
BCL-2	activates	gene	0.80
GENES	activates	gene	0.80
Carcinoma	therapeutic_target	disease	0.75
Inflammation	activates	disease	0.75
Ischemia	regulates	disease	0.75
Cancer	associated_with	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Autophagy	activates	pathway	0.70
Wnt	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
CANCER	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
Apoptosis	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
OXIDATIVE STRESS	activates	gene	0.70
CANCER	associated_with	gene	0.70
Oxidative Stress	activates	pathway	0.70
INFLAMMATION	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Lymphoma	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cardiac	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Cardiac	regulates	disease	0.65
PI3K-AKT-mTOR signaling	participates_in	pathway	0.65
Hypertension	regulates	disease	0.65

Incoming (122)

Source	Relation	Type	Str
BAX	activates	gene	0.90
Separating Microneedles	downregulates	compound	0.85
5-fluorouracil	downregulates	drug	0.80
TP53	regulates	gene	0.70
BAX	interacts_with	gene	0.70
AMBRA1	activates	gene	0.60
AKT	activates	gene	0.60
AKT	phosphorylates	entity	0.60
TLR2	associated_with	gene	0.60
TRKB	causes	gene	0.60
JNK	causes	gene	0.60
MTOR	causes	gene	0.60
AKT	causes	gene	0.60
PI3K	causes	gene	0.60
BDNF	causes	gene	0.60
TAU	causes	gene	0.60
MITOPHAGY	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
IFN	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AGING	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
SYNAPTIC PRUNING	therapeutic_target	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
IFN-Γ	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
LAMP2	associated_with	gene	0.60
TFRC	associated_with	gene	0.60
PPP1CB	associated_with	gene	0.60
TLR2	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
BID	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
PI3K	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
TP53	causes	gene	0.60
BCL-2	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
ERK	inhibits	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
JAK	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ROS	regulates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IL-17	associated_with	gene	0.60
HER2	inhibits	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
PSME3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAD in their description or question text

No additional research found