gene

MANF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MANF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor) gene encoding a neurotrophic factor with ER stress modulation properties, implicated in Parkinson's disease, Alzheimer's disease, and stroke

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🧬 Gene Info

Gene Symbol	MANF
Aliases	Mesencephalic Astrocyte-Derived Neurotrophic Factor
Function	encodes a unique neurotrophic factor with distinctive mechanisms of action distinct from classical neurotrophic factors like BDNF or GDNF.
Molecular Weight	20 kDa
Amino Acids	182 aa
Exons	4
Pathways	Amyloid, Immune Response, Lipid Metabolism, Mitophagy, Oxidative Stress
Ensembl ID	ENSG00000131791
GeneCards	MANF
Human Protein Atlas	MANF
Exon 1	Encodes the signal peptide and N-terminal portion
Exon 2-4	Encode the C-terminal secreted domain with cysteine-rich regions
Associated Diseases	breast cancer cell survival, PRKN E3 ligase activity
Interactions	ACHE, ALZHEIMER, AND, APOPTOSIS, ATF4, AXON
KG Connections	151 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MANF Gene

gene · 1212 words

→

MANF Protein

protein · 873 words

→

Pathway Diagram

graph TD
    MANF["MANF"]
    breast_cancer_cell_survival["breast cancer cell survival"]
    MANF -->|"associated with"| breast_cancer_cell_survival
    mitophagy(["mitophagy"])
    MANF -->|"activates"| mitophagy
    PRKN["PRKN"]
    MANF -->|"interacts with"| PRKN
    PRKN_E3_ligase_activity["PRKN E3 ligase activity"]
    MANF -->|"associated with"| PRKN_E3_ligase_activity
    fatty_acid_oxidation(["fatty acid oxidation"])
    MANF -->|"associated with"| fatty_acid_oxidation
    PARK2["PARK2"]
    MANF -->|"binds"| PARK2
    Als{"Als"}
    MANF -->|"activates"| Als
    Ms{"Ms"}
    MANF -->|"activates"| Ms
    Inflammation{"Inflammation"}
    MANF -->|"activates"| Inflammation
    Cancer{"Cancer"}
    MANF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    MANF -->|"interacts with"| Tumor
    ALS{"ALS"}
    MANF -->|"activates"| ALS
    SENP1["SENP1"]
    SENP1 -->|"modifies"| MANF
    GFAP["GFAP"]
    GFAP -->|"inhibits"| MANF
    GAP43["GAP43"]
    GAP43 -->|"inhibits"| MANF
    ELAVL3["ELAVL3"]
    ELAVL3 -->|"inhibits"| MANF
    MBP["MBP"]
    MBP -->|"inhibits"| MANF
    GENES["GENES"]
    GENES -->|"inhibits"| MANF
    ACHE["ACHE"]
    ACHE -->|"activates"| MANF
    CAT["CAT"]
    CAT -->|"biomarker for"| MANF
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"activates"| MANF
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"biomarker for"| MANF
    GPX4["GPX4"]
    GPX4 -->|"biomarker for"| MANF
    ATF4["ATF4"]
    ATF4 -->|"activates"| MANF
    style MANF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (101)

Target	Relation	Type	Str
PRKN	binds_to	protein	0.95
mitophagy	promotes	process	0.95
breast cancer cell survival	associated_with	phenotype	0.90
PRKN	interacts_with	gene	0.90
PRKN E3 ligase activity	associated_with	phenotype	0.90
breast cancer	therapeutic_target	disease	0.90
mitophagy	activates	pathway	0.90
PRKN	activates	protein	0.90
fatty acid oxidation	associated_with	process	0.85
PARK2	binds	gene	0.80
NEURON	expressed_in	cell_type	0.80
Oxidative Stress	regulates	pathway	0.70
Tumor	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	regulates	disease	0.65
ALS	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
Apoptosis	activates	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
Lipid Metabolism	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
Caspase	activates	protein	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ASTROCYTE	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
Oxidative Stress	activates	pathway	0.60
TAU	therapeutic_target	gene	0.60
Tubulin	inhibits	protein	0.60
Amyloid	regulates	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Neutrophil	activates	cell_type	0.60
Mitophagy	regulates	pathway	0.60

Incoming (50)

Source	Relation	Type	Str
SENP1	de-SUMOylates	protein	0.90
Bpmc	downregulates	compound	0.85
SENP1	modulates	protein	0.85
SENP1	modifies	protein	0.80
OXIDATIVE STRESS	regulates	gene	0.70
CANCER	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
FGF	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
SYN2A	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURON	activates	gene	0.60
MYELIN	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
BPMC	inhibits	gene	0.60
MBP	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
FERROPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
GAP43	inhibits	gene	0.60
ELAVL3	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
SENP1	activates	gene	0.60
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
PRKN	regulates	gene	0.60
TUBULIN	inhibits	gene	0.60
CAT	biomarker_for	gene	0.60
GAP43	regulates	entity	0.60
GFAP	regulates	entity	0.60
ACHE	activates	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ELAVL3	regulates	entity	0.60
GPX4	biomarker_for	gene	0.60
ATF4	activates	gene	0.60
ALZHEIMER	activates	gene	0.50
AMYLOID	co_discussed	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective	0.798	neurodegeneration	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MANF in their description or question text

No additional research found