gene

DNAJC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

137Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

Page for DNAJC6 — DnaJ Heat Shock Protein Family Member A6

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🧬 Gene Info

Gene Symbol	DNAJC6
Full Name	DnaJ Heat Shock Protein Family (Hsp40) Member C6
Aliases	Auxilin-1, Auxilin
Chromosome	19q13.43
Protein Type	Chaperone
Function	Unlike its close relative DNAJC5 (cystinosin), DNAJC6/Auxilin-2 is specifically expressed in neuronal tissues and regulates clathrin-mediated endocytosis[@roosen2014].
Primary Expression	neurons throughout the brain, with particularly high levels in the substantia nigra, basal ganglia, and cerebral [cortex](/brain-
Molecular Weight	70 kDa
Amino Acids	935 aa
Exons	15
Pathways	Oxidative Stress
NCBI Gene ID	9829
Ensembl ID	ENSG00000138193
GeneCards	DNAJC6
Human Protein Atlas	DNAJC6
Associated Diseases	Als, Alzheimer, Huntington, Ms, neurodegeneration, Parkinson
Interactions	ATP13A2, DJ1, FBXO7, GBA1, GLUT4, LRRK2
KG Connections	137 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC6["DNAJC6"]
    Obesity{"Obesity"}
    DNAJC6 -->|"regulates"| Obesity
    Ms{"Ms"}
    DNAJC6 -->|"inhibits"| Ms
    Parkinson{"Parkinson"}
    DNAJC6 -->|"associated with"| Parkinson
    Als{"Als"}
    DNAJC6 -->|"associated with"| Als
    DNAJC6 -->|"associated with"| Ms
    DNAJC6 -->|"therapeutic target"| Als
    Aging{"Aging"}
    DNAJC6 -->|"therapeutic target"| Aging
    LC3["LC3"]
    DNAJC6 -->|"expressed in"| LC3
    Autophagy(["Autophagy"])
    DNAJC6 -->|"expressed in"| Autophagy
    Insulin_Signaling(["Insulin Signaling"])
    DNAJC6 -->|"inhibits"| Insulin_Signaling
    Mitochondrial_Function(["Mitochondrial Function"])
    DNAJC6 -->|"inhibits"| Mitochondrial_Function
    Mtor(["Mtor"])
    DNAJC6 -->|"expressed in"| Mtor
    MTOR["MTOR"]
    MTOR -->|"expressed in"| DNAJC6
    GLUT4["GLUT4"]
    GLUT4 -->|"inhibits"| DNAJC6
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| DNAJC6
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| DNAJC6
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| DNAJC6
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| DNAJC6
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| DNAJC6
    INPP5F["INPP5F"]
    INPP5F -->|"associated with"| DNAJC6
    GAK["GAK"]
    GAK -->|"associated with"| DNAJC6
    SYNJ1["SYNJ1"]
    SYNJ1 -->|"associated with"| DNAJC6
    AUTOPHAGY -->|"associated with"| DNAJC6
    AGING["AGING"]
    AGING -->|"therapeutic target"| DNAJC6
    style DNAJC6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (96)

Target	Relation	Type	Str
SYNJ1	interacts_with	gene	0.80
PRKN	interacts_with	gene	0.80
FBXO7	interacts_with	gene	0.80
PINK1	interacts_with	gene	0.80
PARK7	interacts_with	gene	0.70
SNCA	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
LRRK2	interacts_with	gene	0.70
VPS13C	interacts_with	gene	0.70
neurons	expressed_in	cell_type	0.70
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Spinocerebellar Ataxia	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Parkinson	protects_against	disease	0.65
Obesity	regulates	disease	0.65
Ms	inhibits	disease	0.65
ALS	protects_against	disease	0.65
Alzheimer	associated_with	disease	0.65
Huntington	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Huntington	associated_with	disease	0.60
LC3	expressed_in	gene	0.60
Rb	regulates	protein	0.60
SYNAPSE	therapeutic_target	gene	0.60
SH3GL2	associated_with	gene	0.60
ROS	associated_with	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
DNA	associated_with	gene	0.60
Neuron	regulates	cell_type	0.60
App	regulates	protein	0.60
Parkinson's disease	activates	disease	0.60
CALB2	regulates	gene	0.60
DNAJC5	regulates	gene	0.60
Autophagy	expressed_in	pathway	0.60
Insulin Signaling	inhibits	pathway	0.60
Mitochondrial Function	inhibits	pathway	0.60
Mtor	expressed_in	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Calcium Signaling	protects_against	pathway	0.60
Parkinson's disease	interacts_with	disease	0.60
VPS13C	associated_with	gene	0.60
HUNTINGTON'S DISEASE	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
AND	associated_with	gene	0.60

Incoming (41)

Source	Relation	Type	Str
ATP13A2	interacts_with	gene	0.80
SYNAPSE	associated_with	gene	0.60
MTOR	expressed_in	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
VPS35	regulates	gene	0.60
UCHL1	regulates	gene	0.60
ATP13A2	associated_with	gene	0.60
DJ1	interacts_with	gene	0.60
ATP13A2	expressed_in	gene	0.60
DJ1	expressed_in	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
ALPHA-SYNUCLEIN	associated_with	gene	0.60
INPP5F	associated_with	gene	0.60
HUNTINGTON	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GAK	associated_with	gene	0.60
SYNJ1	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
GLUT4	inhibits	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
CALB2	regulates	gene	0.60
AGING	therapeutic_target	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
ROCK2	regulates	gene	0.60
CALB2	co_expressed_with	gene	0.50
DNAJC5	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJC6 in their description or question text

No additional research found