gene

CHCHD10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHCHD10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

117Connections

0Hypotheses

1Analyses

50Outgoing

20Incoming

0Experiments

1Debates

Summary

CHCHD10 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHCHD10
Full Name	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10
Aliases	CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10
Chromosome	22q11.23
Protein Family	CHCH domain-containing protein family
Function	Together they stabilize the mitochondrial contact site and cristae organizing system (MICOS), which maintains cristae morphology essential for efficient OXPHOS (Genin et al., 2016).
Primary Expression	Motor cortex, Spinal cord, Mitochondria (widespread)
Subcellular Localization	the mitochondrial intermembrane space (IMS), where it plays a role in maintaining cristae morphology and oxidative phosp
Molecular Weight	14 kDa
Amino Acids	182 aa
UniProt ID	Q8WYQ3
Ensembl ID	ENSG00000250479
GeneCards	CHCHD10
Human Protein Atlas	CHCHD10
Associated Diseases	Als, AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, cardiovascular disease, frontotemporal dementia
Interactions	ALS, CCNF, CHCHD2, FTLD, FUS, GBA
KG Connections	117 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHCHD10 — AlphaFold Q8WYQ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHCHD10["CHCHD10"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    CHCHD10 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    CHCHD10 -->|"therapeutic target"| Ms
    Als{"Als"}
    CHCHD10 -->|"associated with"| Als
    C21ORF2["C21ORF2"]
    CHCHD10 -->|"associated with"| C21ORF2
    NEK1["NEK1"]
    CHCHD10 -->|"associated with"| NEK1
    SOD1["SOD1"]
    CHCHD10 -->|"therapeutic target"| SOD1
    TBK1["TBK1"]
    CHCHD10 -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    CHCHD10 -->|"implicated in"| neurodegeneration
    C21ORF2 -->|"associated with"| CHCHD10
    GENES["GENES"]
    GENES -->|"associated with"| CHCHD10
    DNA["DNA"]
    DNA -->|"therapeutic target"| CHCHD10
    style CHCHD10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (97)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
ALS	causes	disease	0.80
neurodegeneration	associated_with	disease	0.70
TDP-43	inhibits	gene	0.65
MOTOR NEURONS	activates	cell_type	0.65
Als	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
NEURON	interacts_with	cell_type	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
OPA1	regulates	gene	0.65
TDP-43	activates	gene	0.65
APOPTOSIS	inhibits	phenotype	0.65
OPA1	causes	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
MITOCHONDRIAL DYSFUNCTION	causes	phenotype	0.65
frontotemporal dementia	causes	disease	0.60
RNA	interacts_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
FUS	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
VCP	associated_with	gene	0.60
CHCHD2	interacts_with	gene	0.60
CHCHD2	associated_with	gene	0.60
C21ORF2	associated_with	gene	0.60
NEK1	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
FUS	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
TGM2	interacts_with	gene	0.60
TMEM175	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
GRN	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
GRN	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
NEK1	interacts_with	gene	0.60
cardiovascular disease	associated_with	disease	0.60
TDP43	interacts_with	gene	0.60
CHCHD2	protects_against	gene	0.60
neurodegeneration	protects_against	disease	0.60
CHCHD2	causes	gene	0.60
CHMP2B	causes	gene	0.60

Incoming (20)

Source	Relation	Type	Str
ALS	causes	gene	0.70
PINK1	treats	gene	0.65
TDP-43	interacts_with	gene	0.65
ALS	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
NEK1	associated_with	gene	0.60
ALS	protects_against	gene	0.60
ALS	interacts_with	gene	0.60
ANXA11	associated_with	gene	0.60
CCNF	associated_with	gene	0.60
ANXA11	causes	gene	0.60
CCNF	causes	gene	0.60
C21ORF2	associated_with	gene	0.60
CCNF	interacts_with	gene	0.60
MATR3	associated_with	gene	0.60
SPINAL CORD	associated_with	brain_region	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors explicitly state that the effects of these novel genes (MATR3, CHCHD

closed · Rounds: 4 · Score: 0.71 · 2026-04-14

Related Research

Hypotheses and analyses mentioning CHCHD10 in their description or question text

No additional research found