| Gene Symbol | OPA1 |
| Full Name | Optic Atrophy 1 |
| Chromosome | 3q29 |
| Protein Type | Protein |
| Function | OPA1 is a nuclear-encoded mitochondrial protein that functions as a large GTPase mediating mitochondrial inner membrane fusion. |
| Subcellular Localization | the inner mitochondrial membrane. It is essential for mitochondrial inner membrane fusion, cristae maintenance, and mito |
| Molecular Weight | 120kDa |
| Amino Acids | 300 aa |
| Pathways | Apoptosis, Lysosomal Degradation, Mitochondrial Function, Mitophagy, Mtor |
| UniProt ID | O60313 |
| NCBI Gene ID | 4976 |
| GeneCards | OPA1 |
| Human Protein Atlas | OPA1 |
| N-terminal GTPase domain | Catalyzes GTP hydrolysis for membrane fusion |
| Middle domain | Mediates oligomerization |
| Associated Diseases | aging, Als, Alzheimer, Cancer |
| Interactions | AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1 |
| KG Connections | 783 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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