protein

IL-18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

458Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for IL-18 Protein

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🔬 Protein Info

Gene Symbol	IL
Full Name	18 - Interleukin-18
Chromosome	11q22.2.
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Pro-inflammatory cytokines	TNF-α, IL-1β
Oxidative stress	ROS, mitochondrial dysfunction
Elevated levels	IL-18 is significantly elevated in CSF and plasma of AD patients compared to healthy controls
Disease correlation	Levels correlate with cognitive decline measured by MMSE and CDR
Pathology association	Associated with amyloid-β plaque deposition and tau hyperphosphorylation
Conversion prediction	Elevated IL-18 predicts conversion from mild cognitive impairment (MCI) to AD
Mechanistic role	Drives neuroinflammation and synaptic dysfunction
Therapeutic target	IL-18 neutralization reduces pathology in AD mouse models
CSF and serum elevation	Increased IL-18 in CSF and serum of PD patients
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL_18(["IL-18"])
    NLRP3["NLRP3"]
    NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    NLRP3_Inflammasome["NLRP3 Inflammasome"]
    Status_Epilepticus["Status Epilepticus"]
    INFLAMMASOME["INFLAMMASOME"]
    Neurodegeneration["Neurodegeneration"]
    Neuroinflammation["Neuroinflammation"]
    Glaucoma["Glaucoma"]
    Ischemia["Ischemia"]
    Neuropathy["Neuropathy"]
    Inflammation["Inflammation"]
    Cancer["Cancer"]
    ALS["ALS"]
    Parkinson["Parkinson"]
    Als["Als"]
    NLRP3 -->|"produces"| IL_18
    NLRP3_Inflammasome_Activation -.-|"associated"| IL_18
    NLRP3_Inflammasome_Activation -->|"activates"| IL_18
    NLRP3_Inflammasome -.-|"associated"| IL_18
    NLRP3 -->|"upstream_of"| IL_18
    IL_18 -->|"biomarker_for"| Status_Epilepticus
    IL_18 -->|"regulates"| INFLAMMASOME
    IL_18 -->|"activates"| Neurodegeneration
    IL_18 -->|"activates"| Neuroinflammation
    IL_18 -->|"activates"| Glaucoma
    IL_18 -->|"activates"| Ischemia
    IL_18 -->|"activates"| Neuropathy
    IL_18 -->|"activates"| Inflammation
    IL_18 -->|"expressed in"| Cancer
    IL_18 -->|"expressed in"| ALS
    IL_18 -->|"activates"| Parkinson
    IL_18 -.-|"associated"| Neuroinflammation
    IL_18 -->|"activates"| ALS
    IL_18 -.-|"associated"| Inflammation
    IL_18 -->|"expressed in"| Als
    style IL_18 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (300)

Target	Relation	Type	Str
Status Epilepticus	biomarker_for	disease	0.80
pyroptosis	participates_in	pathway	0.75
Parkinson	protects_against	disease	0.65
Cirrhosis	causes	disease	0.65
Inflammation	causes	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Als	biomarker_for	disease	0.65
Obesity	causes	disease	0.65
Hypertension	causes	disease	0.65
ALS	causes	disease	0.65
Hypertension	regulates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Inflammation	associated_with	disease	0.65
INFLAMMASOME	regulates	protein	0.65
Als	regulates	disease	0.65
Obesity	regulates	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Carcinoma	causes	disease	0.65
Epilepsy	activates	disease	0.65
Glaucoma	activates	disease	0.65
Ischemia	activates	disease	0.65
Neuropathy	activates	disease	0.65
Inflammation	activates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Stroke	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Pyroptosis	activates	disease	0.65
Als	associated_with	disease	0.65
ALS	activates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Necroptosis	activates	disease	0.65
ALS	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Pyroptosis	inhibits	disease	0.65
Diabetes	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Aging	biomarker_for	disease	0.65
Schizophrenia	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Hepatitis	causes	disease	0.65

Incoming (158)

Source	Relation	Type	Str
NLRP3 Inflammasome Activation	associated_with	process	0.90
NLRP3	associated_with	protein	0.90
NLRP3 Inflammasome	associated_with	mechanism	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
NLRP3	upregulates	protein	0.90
Guhan Yangsheng Jing	downregulates	drug	0.85
GFAP	biomarker_for	gene	0.65
AMPK	transports	gene	0.65
GENES	associated_with	gene	0.60
NFKB1	associated_with	gene	0.60
HSA-MIR-181A-5P	associated_with	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
PER	causes	gene	0.60
TLR4	causes	gene	0.60
TNF	causes	gene	0.60
NLRP3	regulates	gene	0.60
GAIN	regulates	gene	0.60
AGING	activates	gene	0.60
P21	activates	gene	0.60
PTGS2	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
AIM2	activates	gene	0.60
TLR9	regulates	gene	0.60
ANGPT1	activates	gene	0.60
PKC	protects_against	gene	0.60
CASP1	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
EPILEPSY	activates	gene	0.60
TCR	expressed_in	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
IL-1	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
CHAT	protects_against	gene	0.60
GFAP	protects_against	gene	0.60
BAX	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
CD4	expressed_in	gene	0.60
MYD88	activates	gene	0.60
PARKINSON	activates	gene	0.60
SYK	activates	gene	0.60
JNK	activates	gene	0.60
TLR4	regulates	gene	0.60
NLRP6	regulates	gene	0.60
ASC	regulates	gene	0.60
FOXO3	inhibits	gene	0.60
EXOSOMES	inhibits	gene	0.60
STROKE	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-18 in their description or question text

No additional research found