concept

IL-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1613Connections

8Hypotheses

2Analyses

50Outgoing

50Incoming

2Experiments

3Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	IL-1
Key Genes/Proteins	Actin, AEP, AGING, AIF, AIM2, Akt
Related Diseases	Addiction, Aging, Als

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL_1["IL-1"]
    style IL_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IL_1 -->|"contributes to"| Atherosclerosis["Atherosclerosis"]
    IL_1 -->|"mediates"| Inflammatory_Senescence_Associ(Inflammatory Senescence-Associated Secretory Phenotype)
    IL_1 -->|"activates"| Ms["Ms"]
    IL_1 -->|"activates"| Tumor["Tumor"]
    IL_1 -->|"activates"| Inflammation["Inflammation"]
    IL_1 -->|"activates"| Alzheimer["Alzheimer"]
    IL_1 -->|"activates"| Aging["Aging"]
    IL_1 -->|"activates"| Phagocytosis["Phagocytosis"]
    IL_1 -->|"activates"| OCLN([OCLN])
    IL_1 -->|"activates"| MLCK([MLCK])
    NLRP3([NLRP3]) -->|"activates"| IL_1
    IL_17([IL-17]) -->|"co_expressed_with"| IL_1
    DISEASE_ASSOCIATED_MICROGLIA([DISEASE-ASSOCIATED MICROGLIA]) -->|"activates"| IL_1
    TNFR1([TNFR1]) -->|"activates"| IL_1
    AND([AND]) -->|"activates"| IL_1
    MICROGLIA([MICROGLIA]) -->|"activates"| IL_1
    MYELIN([MYELIN]) -->|"activates"| IL_1
    CYTOKINES([CYTOKINES]) -->|"activates"| IL_1
    NEURODEGENERATIVE_DISEASES([NEURODEGENERATIVE DISEASES]) -->|"activates"| IL_1
    PHAGOCYTOSIS([PHAGOCYTOSIS]) -->|"activates"| IL_1

Outgoing (791)

Target	Relation	Type	Str
Cognitive Impairment	associated_with	phenotype	0.85
Systemic Inflammation	mediates	process	0.85
MICROGLIA	upregulates	cell_type	0.80
Inflammatory Senescence-Associated Secretory Phenotype	mediates	phenotype	0.80
Atherosclerosis	contributes_to	disease	0.80
Senescence-associated secretory phenotype	regulates	phenotype	0.80
Frontotemporal Dementia	activates	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Dementia	inhibits	disease	0.65
Aging	activates	disease	0.65
Obesity	activates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	causes	disease	0.65
Anxiety	activates	disease	0.65
Aging	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Necroptosis	activates	disease	0.65
Depression	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Depression	inhibits	disease	0.65
Epilepsy	inhibits	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Hypertension	inhibits	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Diabetes	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Pyroptosis	inhibits	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Diabetes	inhibits	disease	0.65
Aging	causes	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Spinal Cord Injury	regulates	disease	0.65
Huntington	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Anxiety	associated_with	disease	0.65
Depression	regulates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65

Incoming (822)

Source	Relation	Type	Str
NLRP3	activates	protein	0.90
NF-κB	upregulates	protein	0.85
Mitochondrial dysfunction-associated senescence	inhibits	phenotype	0.85
IL-17	interacts_with	protein	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.74
ALS	associated_with	disease	0.66
NF-KB	associated_with	protein	0.66
NLR	associated_with	gene	0.60
MARCH7	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
AMPK	expressed_in	gene	0.60
SIRT1	expressed_in	gene	0.60
STROKE	expressed_in	gene	0.60
NFKB	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
AND	associated_with	gene	0.60
MTDNA	activates	gene	0.60
AND	regulates	gene	0.60
AIM2	associated_with	gene	0.60
STROKE	activates	gene	0.60
CX3CR1	activates	gene	0.60
MAPK	activates	gene	0.60
TDP-43	activates	gene	0.60
CYP17A1	expressed_in	gene	0.60
AMPK	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
PARKINSON	activates	gene	0.60
IBA1	biomarker_for	gene	0.60
MTOR	activates	gene	0.60
GASDERMIN	activates	gene	0.60
SKA2	inhibits	gene	0.60
NLRP3	associated_with	gene	0.60
NAD	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
SYK	activates	gene	0.60
GASDERMIN	associated_with	gene	0.60
STROKE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ROS	biomarker_for	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
SYN1	biomarker_for	gene	0.60
APOE4	associated_with	gene	0.60
APOE Ε4	activates	gene	0.60
CANCER	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
DNA	activates	gene	0.60
ASC	associated_with	gene	0.60
NADH	associated_with	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.663	cell biology	What is the relative contribution of con
Astrocyte IL-1β as Paracrine Mediator of Microglial Compleme	0.660	neuroinflammation	How does sevoflurane-induced NF-κB activ
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.648	neuroinflammation	How do B cells mechanistically orchestra
Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to	0.640	neurodegeneration	What are the mechanisms by which gut mic
NLRP3 Inflammasome Priming Converts SCFA-Sensitive Pyroptosi	0.620	neurodegeneration	How does gut microbiome dysbiosis contri

LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasom	0.617	neurodegeneration	How do perivascular cells specifically r
Circulating hs-CRP as Disease-Modifying Target via Microglia	0.540	immunomics	Systemic immune profiling in neurodegene
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (2)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Network pharmacology analysis of QTJD active compounds and pathways	exploratory	Mycoplasma pneumoniae pneumoni	0.900	0.00	computational network analysis	proposed	N/A
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

closed · Rounds: 4 · Score: 0.76 · 2026-04-23

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

closed · Rounds: 7 · Score: 0.87 · 2026-04-16

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning IL-1 in their description or question text

LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SPP

Score: 0.617 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The proposed LRP1/NLRP3/IL-1β cascade represents a critical mechanistic link betw

Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplificatio

Score: 0.540 · immunomics · 2026-04-25

Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplification

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-

Score: 0.506 · neuroinflammation · 2026-04-14

## Mechanistic Overview TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-1β-Mediated Infl

IL-1

Understanding Entity Pages

Wiki Pages (12)

IL-1α Protein

IL-10 Protein

IL-12 Protein

IL-1 Signaling Pathway in Neurodegeneration

IL-18 - Interleukin-18

Interleukin-1 Beta (IL-1β) - Biomarker

IL-1β Protein - Interleukin-1 Beta

IL-1 Beta Protein

Interleukin-1 beta (IL-1β)

IL-18 Protein

IL-1β Protein

IL-18BP Protein

Pathway Diagram

Outgoing (791)

Incoming (822)

Targeting Hypotheses (8)

Mentioning Analyses (2)

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Experiments (2)

Related Papers (0)

Debates (3)

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Related Research

LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SPP

Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplificatio

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-